SHP1 Products
(Protein-tyrosine Phosphatase 1C (PTPN6))
Categories
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008].
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Featured SHP1 Categories
SHP1 Antibodies
High quality antibodies with extensive validation data.
SHP1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SHP1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SHP1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, FACS, StM
Validations
- (7)
Cat. No.
ABIN6939660
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IP, IHC (fro)
Validations
- (6)
Cat. No.
ABIN2855500
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN1882123
Quantity
400 μL
Datasheet
Datasheet
Recommended SHP1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958967
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380754
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380081
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended SHP1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124693
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316851
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN666674
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SHP1 products
: "Membrane nanoclusters of FcγRI segregate from inhibitory SIRPα upon activation of human macrophages." in: The Journal of cell biology, Vol. 216, Issue 4, pp. 1123-1141, (2017) (PubMed).: "SHP-1 Acts as a Key Regulator of Alloresponses by Modulating LFA-1-Mediated Adhesion in Primary Murine T Cells." in: Molecular and cellular biology, Vol. 36, Issue 24, pp. 3113-3127, (2016) (PubMed).
: "SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1/SHP-1 activation in hepatocellular carcinoma." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 7, pp. 595-605, (2014) (PubMed).
: "Constitutive activation of STAT3 in Sézary syndrome is independent of SHP-1." in: Leukemia, Vol. 26, Issue 2, pp. 323-31, (2012) (PubMed).
: "Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 3, pp. 372-9, (2009) (PubMed).
: "Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 4, pp. 412-9, (2008) (PubMed).
: "Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells." in: The Journal of biological chemistry, Vol. 283, Issue 37, pp. 25544-56, (2008) (PubMed).
: "SHP1 tyrosine phosphatase negatively regulates NPM-ALK tyrosine kinase signaling." in: Blood, Vol. 107, Issue 10, pp. 4130-8, (2006) (PubMed).
: "The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis." in: Nature medicine, Vol. 12, Issue 5, pp. 549-56, (2006) (PubMed).
: "Regulation of SHP-1 tyrosine phosphatase in human platelets by serine phosphorylation at its C terminus." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 40475-83, (2004) (PubMed).
Synonyms and alternative names related to SHP1
protein tyrosine phosphatase, non-receptor type 6 (PTPN6), protein tyrosine phosphatase, non-receptor type 6 (Ptpn6), protein tyrosine phosphatase, non-receptor type 6 (ptpn6), protein tyrosine phosphatase, non-receptor type 6 L homeolog (ptpn6.L), DRPLA, fj22f05, HCPH, Hcph, HPTP1C, me, motheaten, PTP-1C, Ptp1C, Ptph6, ptpn6, SH-PTP1, SHP-1, Shp-1, SHP-1L, SHP1, wu:fj22f05, zgc:55501Protein level used designations for SHP1
- hematopoietic cell phosphatase
- hematopoietic cell protein-tyrosine phosphatase
- protein-tyrosine phosphatase 1C
- protein-tyrosine phosphatase SHP-1
- tyrosine-protein phosphatase non-receptor type 6
- dentatorubro-pallidoluysian atrophy protein
- non-receptor type protein tyrosine phosphatase SHP1
- 70Z-SHP
- PTP-1C
- PTPTY-42
- SH-PTP1
- hemopoietic cell phosphatase
- SH2 phosphatase 1
- protein tyrosine phosphatase, non-receptor type 6 L homeolog
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