SHMT1 Products
(serine Hydroxymethyltransferase 1 (Soluble) (SHMT1))
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This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
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Featured SHMT1 Categories
SHMT1 Antibodies
High quality antibodies with extensive validation data.
SHMT1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SHMT1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SHMT1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (7)
Cat. No.
ABIN562870
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN7256154
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, IHC (p)
Validations
- (4)
Cat. No.
ABIN574342
Quantity
50 μg
Datasheet
Datasheet
Recommended SHMT1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959375
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Sandwich ELISA
Validations
Cat. No.
ABIN419859
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1156948
Quantity
96 tests
Datasheet
Datasheet
Recommended SHMT1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319951
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319953
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125034
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our SHMT1 products
: "Suppression by TFR cells leads to durable and selective inhibition of B cell effector function." in: Nature immunology, Vol. 17, Issue 12, pp. 1436-1446, (2016) (PubMed).: "cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions." in: Cell research, Vol. 25, Issue 4, pp. 429-44, (2015) (PubMed).
: "Mass spectrometric/bioinformatic identification of a protein subset that characterizes the cellular activity of anticancer peptides." in: Journal of proteome research, Vol. 13, Issue 11, pp. 5250-61, (2014) (PubMed).
: "Folate polyglutamylation eliminates dependence of activity on enzyme concentration in mitochondrial serine hydroxymethyltransferases from Arabidopsis thaliana." in: Archives of biochemistry and biophysics, Vol. 536, Issue 1, pp. 87-96, (2013) (PubMed).
: "Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis." in: PLoS genetics, Vol. 8, Issue 3, pp. e1002573, (2012) (PubMed).
Synonyms and alternative names related to SHMT1
serine hydroxymethyltransferase 1 (Shmt1), serine hydroxymethyltransferase 1 (soluble) L homeolog (shmt1.L), serine hydroxymethyltransferase 1 (soluble) (shmt1), microRNA 6778 (MIR6778), serine hydroxymethyltransferase 1 (SHMT1), serine hydroxymethyltransferase 1 (soluble) (Shmt1), serine transhydroxymethyltransferase 1 (SHM1), AI324848, AI385541, C81125, CSHMT, F20D10.50, F20D10_50, LRRGT00032, MEL-32, MGC53442, mShmt, mshmt, mshmt1, mshmt2, SERINE HYDROXYMETHYLTRANSFERASE 1, SERINE TRANSHYDROXYMETHYLASE, SERINE TRANSHYDROXYMETHYLTRANSFERASE, serine transhydroxymethyltransferase 1, Shmt, SHMT, shmt1, SHMT1, Shmt1, SHMT2, STM, zgc:66171, zgc:77524Protein level used designations for SHMT1
- serine hydroxymethyltransferase, cytosolic
- serine hydroxymethyltransferase 1 (soluble)
- zSHMT-1
- SHMT
- glycine hydroxymethyltransferase
- serine methylase
- cytoplasmic serine hydroxymethyltransferase
- cytosolic serine hydroxymethyltransferase
- serine hydroxymethyl transferase
- serine hydroxymethyltransferase 2 (mitochondrial)
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