SHANK2 Products
(SH3 and Multiple Ankyrin Repeat Domains 2 (SHANK2))
Categories
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, an SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined. [provided by RefSeq, Jul 2008].
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Featured SHANK2 Categories
SHANK2 Antibodies
High quality antibodies with extensive validation data.
SHANK2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SHANK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, IF, ICC, AA
Validations
- (1)
- (4)
Cat. No.
ABIN863120
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, IF, ICC, AA
Validations
- (4)
Cat. No.
ABIN2484051
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, IF, ICC, AA
Validations
- (4)
Cat. No.
ABIN2484033
Quantity
100 μg
Datasheet
Datasheet
Recommended SHANK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319924
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SHANK2 products
: "A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders." in: Journal of neurodevelopmental disorders, Vol. 10, Issue 1, pp. 15, (2018) (PubMed).: "Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo." in: Journal of cell science, Vol. 128, Issue 4, pp. 768-80, (2015) (PubMed).
: "Identification and functional characterization of rare SHANK2 variants in schizophrenia." in: Molecular psychiatry, (2015) (PubMed).
: "Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice." in: Molecular neurodegeneration, Vol. 9, Issue 1, pp. 61, (2015) (PubMed).
: "Deletion of Shank1 has minimal effects on the molecular composition and function of glutamatergic afferent postsynapses in the mouse inner ear." in: Hearing research, Vol. 321, pp. 52-64, (2015) (PubMed).
: "S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 5, pp. 1892-904, (2015) (PubMed).
: "Electron tomographic structure and protein composition of isolated rat cerebellar, hippocampal and cortical postsynaptic densities." in: Neuroscience, Vol. 304, pp. 286-301, (2015) (PubMed).
: "Mutations in KPTN cause macrocephaly, neurodevelopmental delay, and seizures." in: American journal of human genetics, Vol. 94, Issue 1, pp. 87-94, (2014) (PubMed).
: "Homer is concentrated at the postsynaptic density and does not redistribute after acute synaptic stimulation." in: Neuroscience, Vol. 266, pp. 80-90, (2014) (PubMed).
: "Casein kinase 2 phosphorylates GluA1 and regulates its surface expression." in: The European journal of neuroscience, Vol. 39, Issue 7, pp. 1148-58, (2014) (PubMed).
Synonyms and alternative names related to SHANK2
SH3 and multiple ankyrin repeat domains 2 (SHANK2), SH3 and multiple ankyrin repeat domains 2 (Shank2), SH3 and multiple ankyrin repeat domains 2 L homeolog (shank2.L), SH3 and multiple ankyrin repeat domains 2 (shank2), SH3 and multiple ankyrin repeat domains protein 2 (LOC100438523), AUTS17, auts17, CORTBP1, cortbp1, CortBP1, CTTNBP1, cttnbp1, MGC122482, mKIAA1022, ProSAP1, prosap1, SHANK, shank2, SHANK2, SPANK-3, spank-3, Spank-3Protein level used designations for SHANK2
- GKAP/SAPAP interacting protein
- SH3 and multiple ankyrin repeat domains protein 2
- cortactin SH3 domain-binding protein
- cortactin-binding protein 1
- proline-rich synapse associated protein 1
- proline-rich synapse-associated protein 1
- cortBP1
- SH3 and multiple ankyrin repeat domains 2
- SH3/ankyrin domain gene 2
- SH3 and multiple ankyrin repeat domains protein 2-like
- GKAP/SAPAP-interacting protein
- proline rich synapse associated protein 1
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