Sh2d1b2 Proteins
(SH2 Domain Protein 1B2 (SH2D1B2))
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family. In SLAM signaling may cooperate with Sh2d1a/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through Cd244/2b4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of Cd244-mediated NK cell function including cytotoxicity and IFN- gamma production, the latter found also by triggering Klra4 and Klrk1 next to Cd244 (PubMed:16127454). Seems to positively regulate Cd244- and Cd84-dependent NK cell functions implicating Cd244-mediated phosphorylation of Vav1 (PubMed:20962259). {ECO:0000269|PubMed:16127454, ECO:0000269|PubMed:20962259}.
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Recommended Sh2d1b2 Proteins
Synonyms and alternative names related to Sh2d1b2
SH2 domain containing 1B2 (Sh2d1b2), EAT-2B, Eat2b, ERT, Ert, Sh2d1cProtein level used designations for Sh2d1b2
- EAT-2-related transducer
- EAT-2B
- SH2 domain protein 1B2
- SH2 domain-containing protein 1B2
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