SH2D1A Products
(SH2 Domain Containing 1A (SH2D1A))
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This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured SH2D1A Categories
SH2D1A Antibodies
High quality antibodies with extensive validation data.
SH2D1A ELISA Kits
Reliable ELISA kits for a wide range of species.
SH2D1A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SH2D1A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (5)
- (4)
Cat. No.
ABIN561703
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (4)
Cat. No.
ABIN3021536
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7169449
Quantity
100 μg
Datasheet
Datasheet
Recommended SH2D1A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4884511
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6386237
Quantity
96 tests
Datasheet
Datasheet
Recommended SH2D1A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125076
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319861
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7319330
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our SH2D1A products
: "Decreased SAP Expression in T Cells from Patients with Systemic Lupus Erythematosus Contributes to Early Signaling Abnormalities and Reduced IL-2 Production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 12, pp. 4915-24, (2016) (PubMed).: "Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance." in: The Journal of allergy and clinical immunology, Vol. 133, Issue 4, pp. 1149-61, (2014) (PubMed).
: "Diagnosing XLP1 in patients with hemophagocytic lymphohistiocytosis." in: The Journal of allergy and clinical immunology, Vol. 134, Issue 6, pp. 1381-1387.e7, (2014) (PubMed).
: "Expansion of somatically reverted memory CD8+ T cells in patients with X-linked lymphoproliferative disease caused by selective pressure from Epstein-Barr virus." in: The Journal of experimental medicine, Vol. 209, Issue 5, pp. 913-24, (2012) (PubMed).
: "Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP." in: PLoS biology, Vol. 9, Issue 11, pp. e1001187, (2011) (PubMed).
: "Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12." in: Immunology and cell biology, Vol. 87, Issue 8, pp. 590-600, (2009) (PubMed).
: "Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency." in: The Journal of clinical investigation, Vol. 119, Issue 10, pp. 2976-89, (2009) (PubMed).
: "The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 29, pp. 11966-71, (2009) (PubMed).
: "SAP binds to CD22 and regulates B cell inhibitory signaling and calcium flux." in: Cellular signalling, Vol. 21, Issue 4, pp. 540-50, (2009) (PubMed).
: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." in: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).
Synonyms and alternative names related to SH2D1A
SH2 domain containing 1A (SH2D1A), SH2 domain containing 1A (Sh2d1a), DSHP, EBVS, Gm686, IMD5, LYP, MTCP1, RGD1562408, SAP, SAP/SH2D1A, SH2D1A, XLP, XLPDProtein level used designations for SH2D1A
- Duncan disease SH2-protein
- SH2 domain-containing protein 1A
- SLAM associated protein/SH2 domain protein 1A
- SLAM-associated protein
- T cell signal transduction molecule SAP
- T-cell signal transduction molecule SAP
- signaling lymphocyte activation molecule-associated protein
- signaling lymphocytic activation molecule-associated protein
- SH2 domain protein 1A
- SH2 domain protein 1A, Duncan's disease (lymphoproliferative syndrome)
- Signaling lymphocytic activation molecule-associated protein
- Duncan disease homolog
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