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SH2B3 Products

(SH2B Adaptor Protein 3 (SH2B3))

Categories

This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq, May 2010].

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Featured SH2B3 Categories

SH2B3 Antibodies

High quality antibodies with extensive validation data.

SH2B3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SH2B3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, FACS
Validations
  • (2)
Cat. No. ABIN6243723
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN185272
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF, ICC
Validations
  • (1)
Cat. No. ABIN6265048
Quantity 100 μL
Datasheet Datasheet

Recommended SH2B3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7405777
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7417174
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3077021
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SH2B3 products

Flister, Endres, Rudemiller, Sarkis, Santarriaga, Roy, Lemke, Geurts, Moreno, Ran, Tsaih, De Pons, Carlson, Tan, Fahrenkrug, Lazarova, Lazar, North, LaViolette, Dwinell, Shull, Jacob: "CXM: a new tool for mapping breast cancer risk in the tumor microenvironment." in: Cancer research, Vol. 74, Issue 22, pp. 6419-29, (2014) (PubMed).

Gery, Cao, Gueller, Xing, Tefferi, Koeffler: "Lnk inhibits myeloproliferative disorder-associated JAK2 mutant, JAK2V617F." in: Journal of leukocyte biology, Vol. 85, Issue 6, pp. 957-65, (2009) (PubMed).

Gery, Gueller, Chumakova, Kawamata, Liu, Koeffler: "Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disorders." in: Blood, Vol. 110, Issue 9, pp. 3360-4, (2007) (PubMed).

Fitau, Boulday, Coulon, Quillard, Charreau: "The adaptor molecule Lnk negatively regulates tumor necrosis factor-alpha-dependent VCAM-1 expression in endothelial cells through inhibition of the ERK1 and -2 pathways." in: The Journal of biological chemistry, Vol. 281, Issue 29, pp. 20148-59, (2006) (PubMed).

Tong, Lodish: "Lnk inhibits Tpo-mpl signaling and Tpo-mediated megakaryocytopoiesis." in: The Journal of experimental medicine, Vol. 200, Issue 5, pp. 569-80, (2004) (PubMed).

Li, He, Schembri-King, Jakes, Hayashi: "Cloning and characterization of human Lnk, an adaptor protein with pleckstrin homology and Src homology 2 domains that can inhibit T cell activation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 10, pp. 5199-206, (2000) (PubMed).

Synonyms and alternative names related to SH2B3

SH2B adaptor protein 3 (SH2B3), SH2B adaptor protein 3 (Sh2b3), AI429800, IDDM20, LNK, Lnk

Protein level used designations for SH2B3

  • lymphocyte adaptor protein
  • SH2B adapter protein 3
  • lymphocyte-specific adapter protein Lnk
  • signal transduction protein Lnk
  • linker of T-cell receptor pathways
  • lymphocyte adapter protein
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