SH2B2 Products
(SH2B Adaptor Protein 2 (SH2B2))
Categories
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt's lymphoma cell lines, it is tyrosine-phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to the Shc/Grb2 pathway. [provided by RefSeq, Jun 2009].
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Featured SH2B2 Categories
SH2B2 Antibodies
High quality antibodies with extensive validation data.
SH2B2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SH2B2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7192349
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, IF, ICC
Validations
- (2)
Cat. No.
ABIN6256908
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (1)
Cat. No.
ABIN7185885
Quantity
100 μg
Datasheet
Datasheet
Recommended SH2B2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319859
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095479
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137272
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SH2B2 products
: "Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling." in: Endocrinology, Vol. 148, Issue 4, pp. 1615-21, (2007) (PubMed).: "Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588." in: The Journal of biological chemistry, Vol. 280, Issue 45, pp. 37827-32, (2005) (PubMed).
: "APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation." in: Biochemical and biophysical research communications, Vol. 330, Issue 3, pp. 1005-13, (2005) (PubMed).
Synonyms and alternative names related to SH2B2
SH2B adaptor protein 2 (SH2B2), SH2B adaptor protein 2 (Sh2b2), APS, ApsProtein level used designations for SH2B2
- SH2 and PH domain-containing adapter protein APS
- SH2B adapter protein 2
- adapter protein with pleckstrin homology and Src homology 2 domains
- adaptor protein with pleckstrin homology and src homology 2 domains
- insulin receptor substrate 5
- SH2B adaptor protein 2
- SH2B adapter protein 2-like
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