SF3A1 Products
(Splicing Factor 3a, Subunit 1 (SF3A1))
Categories
This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family\; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured SF3A1 Categories
SF3A1 Antibodies
High quality antibodies with extensive validation data.
SF3A1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SF3A1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (5)
Cat. No.
ABIN1491272
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC, IF
Validations
- (1)
- (3)
Cat. No.
ABIN2778958
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN1491270
Quantity
100 μL
Datasheet
Datasheet
Recommended SF3A1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6232341
Quantity
96 tests
Datasheet
Datasheet
Recommended SF3A1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319703
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319702
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2731897
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our SF3A1 products
: "Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression." in: Oncotarget, Vol. 8, Issue 14, pp. 22490-22500, (2017) (PubMed).: "Human DBR1 modulates the recycling of snRNPs to affect alternative RNA splicing and contributes to the suppression of cancer development." in: Oncogene, Vol. 36, Issue 38, pp. 5382-5391, (2017) (PubMed).
: "The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 35, Issue 4, pp. 655-66, (2015) (PubMed).
: "The core spliceosome as target and effector of non-canonical ATM signalling." in: Nature, Vol. 523, Issue 7558, pp. 53-8, (2015) (PubMed).
: "Transcriptomic analysis of PNN- and ESRP1-regulated alternative pre-mRNA splicing in human corneal epithelial cells." in: Investigative ophthalmology & visual science, Vol. 54, Issue 1, pp. 697-707, (2013) (PubMed).
: "Isolation and characterization of post-splicing lariat-intron complexes." in: Nucleic acids research, Vol. 37, Issue 3, pp. 891-902, (2009) (PubMed).
: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." in: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).
: "Large-scale characterization of HeLa cell nuclear phosphoproteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 33, pp. 12130-5, (2004) (PubMed).
: "Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation." in: Molecular and cellular biology, Vol. 21, Issue 19, pp. 6406-17, (2001) (PubMed).
: "Functional association of U2 snRNP with the ATP-independent spliceosomal complex E." in: Molecular cell, Vol. 5, Issue 5, pp. 779-87, (2000) (PubMed).
Synonyms and alternative names related to SF3A1
CG16941 gene product from transcript CG16941-RA (CG16941), SWAP/Surp domain-containing protein (sf3a1), splicing factor 3a, subunit 1 (sf3a1), splicing factor 3a, subunit 1 (spl1), splicing factor 3a, subunit 1 (Sf3a1), splicing factor 3a subunit 1 (SF3A1), 1200014H24Rik, 5930416L09Rik, AI159724, DDBDRAFT_0168938, DDBDRAFT_0233180, DDB_0168938, DDB_0233180, Dmel\\CG16941, PRP21, PRPF21, SAP114, SF3a1, SF3a120, SF3A120, si:dz150f13.2, wu:fc38e01, wu:fc50a11, wu:fj37c05, zgc:65786Protein level used designations for SF3A1
- CG16941-PA
- splicing factor 3a, subunit 1
- splicing factor 3A subunit 1
- ubiquitin domain-containing protein
- Splicing factor 3 subunit 1
- SF3a120
- splicing factor 3 subunit 1
- splicing factor 3a, subunit 1, 120kDa
- SAP 114
- pre-mRNA processing 21
- pre-mRNA splicing factor SF3a (120 kDa subunit)
- spliceosome-associated protein 114
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