SETD7 Products
(SET Domain Containing (Lysine Methyltransferase) 7 (SETD7))
Categories
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
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Featured SETD7 Categories
SETD7 Antibodies
High quality antibodies with extensive validation data.
SETD7 ELISA Kits
Reliable ELISA kits for a wide range of species.
SETD7 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SETD7 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Monkey, Rat
Application
WB, ELISA, IHC, FACS, ICC, Neut
Validations
- (5)
Cat. No.
ABIN7193393
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Rat
Application
WB, ELISA, IHC, FACS, ICC, Neut
Validations
- (5)
Cat. No.
ABIN7193392
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (5)
Cat. No.
ABIN566461
Quantity
100 μg
Datasheet
Datasheet
Recommended SETD7 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959453
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951695
Quantity
96 tests
Datasheet
Datasheet
Recommended SETD7 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319680
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7504524
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095428
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SETD7 products
: "Minimally invasive implantation and decreased inflammation reduce osteoinduction of biomaterial." in: Theranostics, Vol. 10, Issue 8, pp. 3533-3545, (2021) (PubMed).: "Setd7 and its contribution to Boron-induced bone regeneration in Boron-mesoporous bioactive glass scaffolds." in: Acta biomaterialia, Vol. 73, pp. 522-530, (2018) (PubMed).
: "SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis." in: Cell reports, Vol. 15, Issue 12, pp. 2733-44, (2016) (PubMed).
: "Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase." in: Molecular cell, Vol. 30, Issue 3, pp. 336-47, (2008) (PubMed).
: "Protein demethylation required for DNA methylation." in: Nature genetics, Vol. 41, Issue 1, pp. 10-1, (2008) (PubMed).
: "The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 26, pp. 10835-40, (2007) (PubMed).
: "Regulation of p53 activity through lysine methylation." in: Nature, Vol. 432, Issue 7015, pp. 353-60, (2004) (PubMed).
: "Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet." in: The EMBO journal, Vol. 22, Issue 2, pp. 292-303, (2003) (PubMed).
: "Structure and catalytic mechanism of the human histone methyltransferase SET7/9." in: Nature, Vol. 421, Issue 6923, pp. 652-6, (2003) (PubMed).
: "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1." in: Genes & development, Vol. 17, Issue 7, pp. 896-911, (2003) (PubMed).
Synonyms and alternative names related to SETD7
SET domain containing lysine methyltransferase 7 (SETD7), SET domain containing (lysine methyltransferase) 7 (setd7), SET domain containing (lysine methyltransferase) 7 (Setd7), 1600028F23Rik, H3K4MT, KMT7, mKIAA1717, SET7, set7, Set7, SET7/9, Set7/9, SET9, zgc:92330, zgc:101860Protein level used designations for SETD7
- H3-K4-HMTase SETD7
- SET domain-containing protein 7
- histone H3-K4 methyltransferase SETD7
- histone H3-lysine 4-specific methyltransferase
- histone-lysine N-methyltransferase SETD7
- lysine N-methyltransferase 7
- H3-K4 methyltransferase
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