SET Domain, Bifurcated 1 Products
(SET Domain, Bifurcated 1 (SETDB1))
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This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011].
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Featured SET Domain, Bifurcated 1 Categories
SET Domain, Bifurcated 1 Antibodies
High quality antibodies with extensive validation data.
SET Domain, Bifurcated 1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SET Domain, Bifurcated 1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN523280
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7155521
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Monkey, Mouse
Application
WB, ELISA, ICC
Validations
- (1)
- (2)
Cat. No.
ABIN969394
Quantity
100 μL
Datasheet
Datasheet
Recommended SET Domain, Bifurcated 1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6204130
Quantity
96 tests
Datasheet
Datasheet
Recommended SET Domain, Bifurcated 1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319683
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319685
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus
Validations
- (2)
Cat. No.
ABIN2669700
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our SET Domain, Bifurcated 1 products
: "IFI16, a nuclear innate immune DNA sensor, mediates epigenetic silencing of herpesvirus genomes by its association with H3K9 methyltransferases SUV39H1 and GLP." in: eLife, Vol. 8, (2019) (PubMed).: "DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting the Impact of Perinatal Diet on ..." in: Diabetes, Vol. 65, Issue 8, pp. 2258-67, (2016) (PubMed).
: "Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis." in: Oncogene, Vol. 33, Issue 21, pp. 2807-13, (2014) (PubMed).
: "Silica nanoparticles induce cytokine responses in lung epithelial cells through activation of a p38/TACE/TGF-α/EGFR-pathway and NF-κΒ signalling." in: Toxicology and applied pharmacology, Vol. 279, Issue 1, pp. 76-86, (2014) (PubMed).
: "The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset." in: Nature, Vol. 471, Issue 7339, pp. 513-7, (2011) (PubMed).
: "Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression." in: Molecular and cellular biochemistry, Vol. 305, Issue 1-2, pp. 35-44, (2007) (PubMed).
: "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC." in: Proteomics, Vol. 5, Issue 14, pp. 3589-99, (2005) (PubMed).
: "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins." in: The Journal of biological chemistry, Vol. 280, Issue 14, pp. 13928-35, (2005) (PubMed).
: "Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly." in: Molecular cell, Vol. 15, Issue 4, pp. 595-605, (2004) (PubMed).
: "mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression." in: Molecular cell, Vol. 12, Issue 2, pp. 475-87, (2003) (PubMed).
Synonyms and alternative names related to SET Domain, Bifurcated 1
SET domain bifurcated 1 (SETDB1), SET domain, bifurcated 1 (Setdb1), myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (MLLT11), histone-lysine N-methyltransferase SETDB1 (LOC100120014), histone-lysine N-methyltransferase SETDB1 (LOC100461671), SET domain, bifurcated 1a (setdb1a), SET domain bifurcated 1 L homeolog (setdb1.L), SET domain bifurcated 1 (Setdb1), SET domain, bifurcated 1b (setdb1b), AU022152, ESET, fc07d03, H3-K9-HMTase4, im:7143091, KG1T, KMT1E, mKIAA0067, NV10069, SETDB1, si:ch211-81a5.6, TDRD21, wu:fa04a12, wu:fc07d03, wu:fj80h02, zgc:152899Protein level used designations for SET Domain, Bifurcated 1
- ERG-associated protein with SET domain
- ERG-associated protein with a SET domain, ESET
- H3-K9-HMTase 4
- histone H3-K9 methyltransferase 4
- histone-lysine N-methyltransferase SETDB1
- histone-lysine N-methyltransferase, H3lysine-9 specific 4
- lysine N-methyltransferase 1E
- tudor domain containing 21
- SET domain ERG-associated histone methyltransferase
- SET domain, bifurcated 1
- histone-lysine N-methyltransferase SETDB1-like
- histone-lysine N-methyltransferase SETDB1-A
- histone-lysine N-methyltransferase SETDB1-B
Did you look for something else?
- SET Domain Containing (Lysine Methyltransferase) 8
- SET Binding Factor 2
- SET and MYND Domain Containing 2a
- SET and MYND Domain Containing 1
- Sestrin 2
- SESTD1
- SESN3
- SESN1
- Seryl-tRNA Synthetase
- serum/glucocorticoid Regulated Kinase 2
- serum/glucocorticoid Regulated Kinase 1
- Serum Amyloid A3 Pseudogene
- SERTM1
- SERTAD4-AS1
- SERTAD4
- SERTAD3
- SERTAD2
- SERTAD1
- Serratia Marcescens
- Serrate RNA Effector Molecule
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