Septin 2 Products
(Septin 2 (SEPT2))
Categories
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).
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Featured Septin 2 Categories
Septin 2 Antibodies
High quality antibodies with extensive validation data.
Septin 2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Septin 2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
Cat. No.
ABIN308439
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN518271
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7168865
Quantity
100 μg
Datasheet
Datasheet
Recommended Septin 2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975081
Quantity
96 tests
Datasheet
Datasheet
Recommended Septin 2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125024
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319542
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319544
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Septin 2 products
: "Septin-2 is overexpressed in epithelial ovarian cancer and mediates proliferation via regulation of cellular metabolic proteins." in: Oncotarget, Vol. 10, Issue 31, pp. 2959-2972, (2019) (PubMed).: "Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion." in: The Journal of cell biology, Vol. 214, Issue 5, pp. 517-27, (2016) (PubMed).
: "Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion." in: mBio, Vol. 5, Issue 5, pp. e01802-14, (2014) (PubMed).
: "Modulation of septin and molecular motor recruitment in the microtubule environment of the Taxol-resistant human breast cancer cell line MDA-MB-231." in: Proteomics, Vol. 11, Issue 19, pp. 3877-86, (2011) (PubMed).
: "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7." in: Cell, Vol. 130, Issue 5, pp. 837-50, (2007) (PubMed).
Synonyms and alternative names related to Septin 2
septin 2 (SEPT2), septin 2 (Sept2), septin 2 (sept2), septin 2 L homeolog (sept2.L), septin 2-like (SEPT2L), COG1487; VapC; putative nucleic acid-binding protein; contains PIN domain (sepT2), septin 2 S homeolog (sept2.S), AW208991, DIFF6, diff6, hNedd5, hnedd5, mKIAA0158, Nedd-5, NEDD5, Nedd5, nedd5, Pnutl3, pnutl3, Sep-02, sept2, SEPT2, sept2-B, septa, Septin-2, Septin-2A, Septin-2B, Septin-A, Vesp11, wu:fb52g01, wu:fb99a01, xlseptaProtein level used designations for Septin 2
- NEDD-5
- neural precursor cell expressed developmentally down-regulated protein 5
- neural precursor cell expressed, developmentally down-regulated 5
- septin-2
- neural precursor cell expressed, developmentally down-regulated gene 5
- vascular endothelial cell specific protein 11
- septin A
- septin-2A
- septin 2
- ANL34
- septin-2B
- Septin-2
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