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SENP1 Products

(SUMO1/sentrin Specific Peptidase 1 (SENP1))

Categories

This gene encodes a cysteine protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This protease regulates SUMO pathways by deconjugating sumoylated proteins. This protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012].

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Featured SENP1 Categories

SENP1 Antibodies

High quality antibodies with extensive validation data.

SENP1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SENP1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (3)
Cat. No. ABIN388042
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN6147534
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7168833
Quantity 100 μg
Datasheet Datasheet

Recommended SENP1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381484
Quantity 96 tests
Datasheet Datasheet

Recommended SENP1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319503
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3095402
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3134548
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SENP1 products

Zhang, Wang, Zhu, Huang, Deng, Cheng, Zhu, Li: "SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion." in: Cell death & disease, Vol. 7, Issue 11, pp. e2484, (2016) (PubMed).

Rohira, Chen, Allen, Johnson: "Covalent small ubiquitin-like modifier (SUMO) modification of Maf1 protein controls RNA polymerase III-dependent transcription repression." in: The Journal of biological chemistry, Vol. 288, Issue 26, pp. 19288-95, (2013) (PubMed).

Bawa-Khalfe, Cheng, Lin, Ittmann, Yeh: "SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25859-66, (2010) (PubMed).

Yu, Ji, Zhang, Renda, He, Lin, Cheng, Chen, Krause, Min: "SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis." in: The Journal of experimental medicine, Vol. 207, Issue 6, pp. 1183-95, (2010) (PubMed).

Sharma, Murillas, Zhang, Kuehn: "N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies." in: Journal of cell science, Vol. 123, Issue Pt 8, pp. 1227-34, (2010) (PubMed).

van Hagen, Overmeer, Abolvardi, Vertegaal: "RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2alpha." in: Nucleic acids research, Vol. 38, Issue 6, pp. 1922-31, (2010) (PubMed).

Li, Luo, Yu, Lin, Luo, Zhang, He, Kim, Kim, Tang, Min: "SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis." in: Cell death and differentiation, Vol. 15, Issue 4, pp. 739-50, (2008) (PubMed).

La Salle, Sun, Zhang, Matunis, Handel: "Developmental control of sumoylation pathway proteins in mouse male germ cells." in: Developmental biology, Vol. 321, Issue 1, pp. 227-37, (2008) (PubMed).

Cheng, Kang, Zhang, Yeh: "SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia." in: Cell, Vol. 131, Issue 3, pp. 584-95, (2007) (PubMed).

Meinecke, Cinski, Baier, Peters, Dankbar, Wille, Drynda, Mendoza, Gay, Hay, Ink, Gay, Pap: "Modification of nuclear PML protein by SUMO-1 regulates Fas-induced apoptosis in rheumatoid arthritis synovial fibroblasts." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 12, pp. 5073-8, (2007) (PubMed).

Synonyms and alternative names related to SENP1

SUMO1/sentrin specific peptidase 1 (SENP1), SUMO1/sentrin specific peptidase 1 (Senp1), SUMO1/sentrin specific peptidase 1 S homeolog (senp1.S), sentrin/SUMO-specific protease 1 (Senp1), SUMO1/sentrin specific peptidase 1 L homeolog (senp1.L), SUMO1/sentrin specific peptidase 1 (senp1), 2310046A20Rik, D15Ertd528e, E330036L07Rik, senp1, SENP1, Senp1, senp1a, senp1b, SuPr-2, suPr-2, xsenp1

Protein level used designations for SENP1

  • SUMO1/sentrin specific protease 1
  • sentrin-specific protease 1
  • sentrin/SUMO-specific protease SENP1
  • SUMO-1 protease 2
  • Sumo1/sentrin/SMT3 specific peptidase 1
  • SUMO-specific protease U1p1
  • sentrin specific protease 1a
  • SUMO1/sentrin specific peptidase 1
  • sentrin/SUMO-specific protease 1
  • similar to Sentrin-specific protease 1 (Sentrin/SUMO-specific protease SENP1)
  • sentrin specific protease 1b
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