SEMA4D/CD100 Products
(Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4D (SEMA4D))
Categories
Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system\; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA (By similarity).
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Featured SEMA4D/CD100 Categories
SEMA4D/CD100 Antibodies
High quality antibodies with extensive validation data.
SEMA4D/CD100 ELISA Kits
Reliable ELISA kits for a wide range of species.
SEMA4D/CD100 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SEMA4D/CD100 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, IHC, ELISA
Validations
- (7)
Cat. No.
ABIN5611304
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (3)
Cat. No.
ABIN564579
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
FACS
Validations
- (3)
Cat. No.
ABIN7505849
Quantity
100 tests
Datasheet
Datasheet
Recommended SEMA4D/CD100 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6959355
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962543
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959356
Quantity
96 tests
Datasheet
Datasheet
Recommended SEMA4D/CD100 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275566
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275561
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275565
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SEMA4D/CD100 products
: "A high-sensitivity enzyme immunoassay for the quantification of soluble human semaphorin 4D in plasma." in: Analytical biochemistry, Vol. 574, pp. 15-22, (2020) (PubMed).: "Pathological and therapeutic implications of eosinophil-derived semaphorin 4D in eosinophilic chronic rhinosinusitis. ..." in: The Journal of allergy and clinical immunology, Vol. 145, Issue 3, pp. 843-854.e4, (2020) (PubMed).
: "Sema4D/PlexinB1 promotes endothelial differentiation of dental pulp stem cells via activation of AKT and ERK1/2 signaling." in: Journal of cellular biochemistry, Vol. 120, Issue 8, pp. 13614-13624, (2019) (PubMed).
: "Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma." in: Blood cancer journal, Vol. 8, Issue 5, pp. 42, (2019) (PubMed).
: "Semaphorin 4D Enhances Angiogenic Potential and Suppresses Osteo-/Odontogenic Differentiation of Human Dental Pulp Stem Cells." in: Journal of endodontics, Vol. 43, Issue 2, pp. 297-305, (2018) (PubMed).
: "Sema4D/PlexinB1 inhibition ameliorates blood-brain barrier damage and improves outcome after stroke in rats." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 32, Issue 4, pp. 2181-2196, (2018) (PubMed).
: "Genome-wide analysis identifies an african-specific variant in SEMA4D associated with body mass index." in: Obesity (Silver Spring, Md.), Vol. 25, Issue 4, pp. 794-800, (2017) (PubMed).
: "Interferon-α-induced CD100 on naïve CD8+ T cells enhances antiviral responses to hepatitis C infection through CD72 signal transduction." in: The Journal of international medical research, Vol. 45, Issue 1, pp. 89-100, (2017) (PubMed).
: "Circulating semaphorin-4D and plexin-B1 levels in postmenopausal women with low bone mass: the 3-month effect of zoledronic acid, denosumab or teriparatide treatment." in: Expert opinion on therapeutic targets, pp. 1-8, (2014) (PubMed).
: "CD100 up-regulation induced by interferon-α on B cells is related to hepatitis C virus infection." in: PLoS ONE, Vol. 9, Issue 12, pp. e113338, (2014) (PubMed).
Synonyms and alternative names related to SEMA4D/CD100
semaphorin 4D (Sema4d), semaphorin 4D (SEMA4D), sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (Sema4d), C9orf164, CD100, coll-4, COLL-4, M-sema-G, Semacl2, SEMAJ, Semaj, Semcl2Protein level used designations for SEMA4D/CD100
- semaphorin-4D
- A8
- BB18
- GR3
- sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D
- M-sema G
- sema J
- semaphorin H
- semaphorin-C-like 2
- semaphorin-J
- semaphorin 4D
- collapsin-4
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