Sema4a Products
(Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a))
Categories
This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010].
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Featured Sema4a Categories
Sema4a Antibodies
High quality antibodies with extensive validation data.
Sema4a ELISA Kits
Reliable ELISA kits for a wide range of species.
Sema4a Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Sema4a Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6259185
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN7270199
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, FACS
Validations
- (4)
Cat. No.
ABIN7043610
Quantity
0.2 mL
Datasheet
Datasheet
Recommended Sema4a ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959353
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN822446
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4884441
Quantity
96 tests
Datasheet
Datasheet
Recommended Sema4a Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1319469
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319471
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Human Cells
Validations
- (1)
Cat. No.
ABIN7320641
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Sema4a products
: "Semaphorin4A and H-ferritin utilize Tim-1 on human oligodendrocytes: A novel neuro-immune axis." in: Glia, Vol. 66, Issue 7, pp. 1317-1330, (2018) (PubMed).: "Semaphorin 4A enhances lung fibrosis through activation of Akt via PlexinD1 receptor." in: Journal of biosciences, Vol. 40, Issue 5, pp. 855-62, (2015) (PubMed).
: "Neuroimmune semaphorin 4A as a drug and drug target for asthma." in: International immunopharmacology, Vol. 17, Issue 3, pp. 568-75, (2013) (PubMed).
: "Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis." in: Nature, Vol. 501, Issue 7466, pp. 252-6, (2013) (PubMed).
Synonyms and alternative names related to Sema4a
semaphorin 4A (SEMA4A), sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (sema4a), sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a), semaphorin 4A (Sema4a), AI132332, CORD10, RP35, SEMA4A, SEMAB, Semab, SEMB, SemBProtein level used designations for Sema4a
- semaphorin B
- sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
- semaphorin-4A
- semaphorin-4A-like
- sema B
- semaphorin-B
- semaphorin 4A
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