SELPLG Products
(Selectin P Ligand (SELPLG))
Categories
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011].
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Featured SELPLG Categories
SELPLG Antibodies
High quality antibodies with extensive validation data.
SELPLG ELISA Kits
Reliable ELISA kits for a wide range of species.
SELPLG Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SELPLG Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, WB, ELISA, IHC (p)
Validations
- (4)
Cat. No.
ABIN679298
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS
Validations
- (3)
Cat. No.
ABIN489932
Quantity
100 tests
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (3)
Cat. No.
ABIN3022340
Quantity
100 μL
Datasheet
Datasheet
Recommended SELPLG ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959333
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6959334
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959335
Quantity
96 tests
Datasheet
Datasheet
Recommended SELPLG Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275485
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275487
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN6961157
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our SELPLG products
: "Engineering Delivery of Nonbiologics Using Poly(lactic-co-glycolic acid) Nanoparticles for Repair of Disrupted Brain Endothelium." in: ACS omega, Vol. 5, Issue 24, pp. 14730-14740, (2020) (PubMed).: "Adhesion of Toxoplasma gondii tachyzoite-infected vehicle leukocytes to capillary endothelial cells triggers timely parasite egression." in: Scientific reports, Vol. 7, Issue 1, pp. 5675, (2019) (PubMed).
: "The intestinal nematode inhibits T-cell reactivity by targeting P-GP activity." in: Parasite immunology, Vol. 39, Issue 12, (2018) (PubMed).
: "C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation." in: eLife, Vol. 7, (2018) (PubMed).
: "Up-Regulated Expression of Matrix Metalloproteinases in Endothelial Cells Mediates Platelet Microvesicle-Induced Angiogenesis." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 41, Issue 6, pp. 2319-2332, (2017) (PubMed).
: "Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation." in: EBioMedicine, Vol. 9, pp. 180-94, (2016) (PubMed).
: "Endoplasmic reticulum stress contributes to ferritin molecules-mediated macrophage migration via P-selectin glycoprotein ligand-1." in: Molecular nutrition & food research, Vol. 61, Issue 4, (2016) (PubMed).
: "Basic motifs target PSGL-1, CD43, and CD44 to plasma membrane sites where HIV-1 assembles." in: Journal of virology, Vol. 89, Issue 1, pp. 454-67, (2014) (PubMed).
: "Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1." in: PLoS ONE, Vol. 8, Issue 11, pp. e78988, (2014) (PubMed).
: "Angiotensin II type 1A receptor signaling facilitates tumor metastasis formation through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells." in: The American journal of pathology, Vol. 182, Issue 2, pp. 553-64, (2013) (PubMed).
Synonyms and alternative names related to SELPLG
selectin P ligand (SELPLG), selectin, platelet (p-selectin) ligand (Selplg), clasper (cla), selectin P ligand (Selplg), CD162, CLA, PSGL-1, Psgl-1, PSGL1, Psgl1, Selp1, SELPG, Selpl, SELPLGProtein level used designations for SELPLG
- P-selectin glycoprotein ligand 1
- cutaneous lymphocyte-associated associated antigen
- selectin P ligand
- P-selectin glycoprotein ligand 1 propeptide
- P-selectin glycoprotein ligand-1
- leukocyte cell surface adhesion molecule
- selectin, platelet (p-selectin) ligand
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