SCN8A Products
(Sodium Channel, Voltage-Gated, Type VIII, alpha (SCN8A))
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This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with mental retardation, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010].
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Featured SCN8A Categories
SCN8A Antibodies
High quality antibodies with extensive validation data.
SCN8A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SCN8A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (3)
Cat. No.
ABIN520023
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
WB, IHC, IF
Validations
- (3)
Cat. No.
ABIN7075647
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN2776200
Quantity
100 μL
Datasheet
Datasheet
Recommended SCN8A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319283
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our SCN8A products
: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." in: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, (2015) (PubMed).: "Axon initial segment-associated microglia." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 5, pp. 2283-92, (2015) (PubMed).
: "BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 18, pp. 7082-94, (2015) (PubMed).
: "The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening." in: PLoS ONE, Vol. 10, Issue 6, pp. e0128578, (2015) (PubMed).
: "A unique ion channel clustering domain on the axon initial segment of mammalian neurons." in: The Journal of comparative neurology, Vol. 522, Issue 11, pp. 2594-608, (2014) (PubMed).
: "Glial ankyrins facilitate paranodal axoglial junction assembly." in: Nature neuroscience, Vol. 17, Issue 12, pp. 1673-81, (2014) (PubMed).
: "Blast wave exposure impairs memory and decreases axon initial segment length." in: Journal of neurotrauma, Vol. 30, Issue 9, pp. 741-51, (2013) (PubMed).
: "Aberrant sodium channel activity in the complex seizure disorder of Celf4 mutant mice." in: The Journal of physiology, Vol. 591, Issue Pt 1, pp. 241-55, (2013) (PubMed).
: "Effects of adult neural precursor-derived myelination on axonal function in the perinatal congenitally dysmyelinated brain: optimizing time of intervention, developing accurate prediction models, and ..." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 29, pp. 11899-915, (2013) (PubMed).
: "FGF14 localization and organization of the axon initial segment." in: Molecular and cellular neurosciences, Vol. 56, pp. 393-403, (2013) (PubMed).
Synonyms and alternative names related to SCN8A
sodium voltage-gated channel alpha subunit 8 (SCN8A), sodium voltage-gated channel alpha subunit 8 (Scn8a), sodium channel, voltage-gated, type VIII, alpha (Scn8a), AI853486, C630029C19Rik, CERIII, CIAT, dmu, EIEE13, MED, med, mnd-2, mnd2, NaCh6, Nav1.6, nmf2, nmf58, nmf335, nur14, PN4, sealProtein level used designations for SCN8A
- hNa6/Scn8a voltage-gated sodium channel
- sodium channel protein type 8 subunit alpha
- voltage-gated sodium channel subunit alpha Nav1.6
- Na+ channel
- PN4
- naCh6
- peripheral nerve protein type 4
- sodium channel 6
- sodium channel protein type VIII subunit alpha
- sodium channel voltage-gated type VIII alpha polypeptide
- sodium channel, voltage-gated, type 8, alpha polypeptide
- sodium channel, voltage-gated, type 8, alpha subunit
- sodium channel, voltage-gated, type VIII, alpha polypeptide
- ataxia 3
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