SCN1A Products
(Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))
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The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.[provided by RefSeq, Jan 2011].
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Featured SCN1A Categories
SCN1A Antibodies
High quality antibodies with extensive validation data.
Recommended SCN1A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IF
Validations
- (2)
Cat. No.
ABIN7169916
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (2)
Cat. No.
ABIN6243309
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7238339
Quantity
200 μL
Datasheet
Datasheet
Latest Publications for our SCN1A products
: "Sodium channel β1 subunit localizes to axon initial segments of excitatory and inhibitory neurons and shows regional heterogeneity in mouse brain." in: The Journal of comparative neurology, Vol. 523, Issue 5, pp. 814-30, (2015) (PubMed).: "Acceleration of conduction velocity linked to clustering of nodal components precedes myelination." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 3, pp. E321-8, (2015) (PubMed).
: "The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening." in: PLoS ONE, Vol. 10, Issue 6, pp. e0128578, (2015) (PubMed).
: "Molecular identity of axonal sodium channels in human cortical pyramidal cells." in: Frontiers in cellular neuroscience, Vol. 8, pp. 297, (2014) (PubMed).
: "Action potential initiation in neocortical inhibitory interneurons." in: PLoS biology, Vol. 12, Issue 9, pp. e1001944, (2014) (PubMed).
: "Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents." in: ACS chemical biology, Vol. 9, Issue 5, pp. 1204-12, (2014) (PubMed).
: "Altered sleep regulation in a mouse model of SCN1A-derived genetic epilepsy with febrile seizures plus (GEFS+)." in: Epilepsia, Vol. 54, Issue 4, pp. 625-34, (2013) (PubMed).
: "FGF14 localization and organization of the axon initial segment." in: Molecular and cellular neurosciences, Vol. 56, pp. 393-403, (2013) (PubMed).
: "Interaction between the transcriptional corepressor Sin3B and voltage-gated sodium channels modulates functional channel expression." in: Scientific reports, Vol. 3, pp. 2809, (2013) (PubMed).
: "NaV1.1 channels in axon initial segments of bipolar cells augment input to magnocellular visual pathways in the primate retina." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 41, pp. 16045-59, (2013) (PubMed).
Synonyms and alternative names related to SCN1A
sodium voltage-gated channel alpha subunit 1 (SCN1A), sodium voltage-gated channel alpha subunit 9 (SCN9A), sodium channel, voltage-gated, type I, alpha (Scn1a), sodium voltage-gated channel alpha subunit 1 (Scn1a), B230332M13, EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SCN1A, SCN9A, SMEIProtein level used designations for SCN1A
- sodium channel, voltage-gated, type IX, alpha subunit
- voltage-gated sodium channel I
- sodium channel, voltage-gated, type I, alpha subunit
- sodium channel protein brain I subunit alpha
- sodium channel protein type 1 subunit alpha
- sodium channel protein type I subunit alpha
- sodium channel protein, brain I subunit alpha
- sodium channel voltage-gated type I alpha polypeptide
- sodium channel, voltage-gated, type 1, alpha polypeptide
- sodium channel, voltage-gated, type I, alpha polypeptide
- voltage-gated sodium channel subunit alpha Nav1.1
- sodium channel protein, brain I alpha subunit
- sodium channel voltage gated type 1 alpha subunit
- sodium channel voltage-gated type I alpha
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