Sclerostin Products
(Sclerostin (SOST))
Categories
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008].
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Featured Sclerostin Categories
Sclerostin Antibodies
High quality antibodies with extensive validation data.
Sclerostin ELISA Kits
Reliable ELISA kits for a wide range of species.
Sclerostin Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Sclerostin Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (2)
- (5)
Cat. No.
ABIN390193
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (1)
- (2)
Cat. No.
ABIN7435190
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7168635
Quantity
100 μL
Datasheet
Datasheet
Recommended Sclerostin ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6959272
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6959273
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
Cat. No.
ABIN6959274
Quantity
96 tests
Datasheet
Datasheet
Recommended Sclerostin Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275636
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275637
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7275635
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our Sclerostin products
: "Targeting SOST using a small-molecule compound retards breast cancer bone metastasis." in: Molecular cancer, Vol. 21, Issue 1, pp. 228, (2023) (PubMed).: "Significance of acPWV for Survival of Hemodialysis Patients." in: Medicina (Kaunas, Lithuania), Vol. 56, Issue 9, (2020) (PubMed).
: "Evaluation of serum fibroblast growth factor-23 in patients with axial spondyloarthritis and its association with sclerostin, inflammation, and spinal damage." in: Rheumatology international, Vol. 39, Issue 5, pp. 835-840, (2020) (PubMed).
: "Role of sclerostin and dkk1 in bone remodeling in type 2 diabetic patients." in: Endocrine research, Vol. 43, Issue 1, pp. 29-38, (2018) (PubMed).
: "Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips." in: Calcified tissue international, Vol. 100, Issue 6, pp. 609-618, (2018) (PubMed).
: "The effect of levetiracetam on rat bone mineral density, bone structure and biochemical markers of bone metabolism." in: European journal of pharmacology, Vol. 824, pp. 115-119, (2018) (PubMed).
: "Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement." in: PLoS ONE, Vol. 12, Issue 1, pp. e0167312, (2017) (PubMed).
: "Upregulated serum sclerostin level in the T2DM patients with femur fracture inhibits the expression of bone formation/remodeling-associated biomarkers via antagonizing Wnt signaling." in: European review for medical and pharmacological sciences, Vol. 21, Issue 3, pp. 470-478, (2017) (PubMed).
: "DMP-1-mediated Ghr gene recombination compromises skeletal development and impairs skeletal response to intermittent PTH." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 2, pp. 635-52, (2016) (PubMed).
: "Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 31, Issue 10, pp. 1791-1802, (2016) (PubMed).
Synonyms and alternative names related to Sclerostin
sclerostin (LOC100313724), sclerostin (SOST), sclerostin (Sost), 5430411E23Rik, CDD, LOC100313724, VBCHProtein level used designations for Sclerostin
- sclerostin
- sclerosteosis
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