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SCARB2 Products

(Scavenger Receptor Class B, Member 2 (SCARB2))

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The protein encoded by this gene is a type III glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstruction, deafness, and peripheral neuropathy. Further studies in human showed that this protein is a ubiquitously expressed protein and that it is involved in the pathogenesis of HFMD (hand, foot, and mouth disease) caused by enterovirus-71 and possibly by coxsackievirus A16. Mutations in this gene caused an autosomal recessive progressive myoclonic epilepsy-4 (EPM4), also known as action myoclonus-renal failure syndrome (AMRF). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011].

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Featured SCARB2 Categories

SCARB2 Antibodies

High quality antibodies with extensive validation data.

SCARB2 ELISA Kits

Reliable ELISA kits for a wide range of species.

SCARB2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SCARB2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7158800
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (3)
Cat. No. ABIN873185
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (3)
Cat. No. ABIN560246
Quantity 50 μL
Datasheet Datasheet

Recommended SCARB2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN2703297
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6384371
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1141297
Quantity 96 tests
Datasheet Datasheet

Recommended SCARB2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7320637
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Source Human Cells
Validations
  • (1)
Cat. No. ABIN7320638
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1319219
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our SCARB2 products

Chen, Liu, Zhou, Zhao, Ren, Xiao, Zhu, Qi: "Endophilin-A2-mediated endocytic pathway is critical for enterovirus 71 entry into caco-2 cells." in: Emerging microbes & infections, Vol. 8, Issue 1, pp. 773-786, (2019) (PubMed).

Sun, Tijsma, Mirabelli, Baggen, Wahedi, Franco, De Palma, Leyssen, Verbeken, van Kuppeveld, Neyts, Thibaut: "Intra-host emergence of an enterovirus A71 variant with enhanced PSGL1 usage and neurovirulence." in: Emerging microbes & infections, Vol. 8, Issue 1, pp. 1076-1085, (2019) (PubMed).

Truschel, Clayton, Beckel, Yabes, Yao, Wolf-Johnston, Birder, Apodaca: "Age-related endolysosome dysfunction in the rat urothelium." in: PLoS ONE, Vol. 13, Issue 6, pp. e0198817, (2018) (PubMed).

Wilden, Molina, Feuerborn, Boyle, Lee: "Glutamine-dependent lysosome homeostatic changes induced by starvation and lysosome inhibition." in: Biochimica et biophysica acta. Molecular cell research, Vol. 1865, Issue 9, pp. 1356-1367, (2018) (PubMed).

Gurda, De Guilhem De Lataillade, Bell, Zhu, Yu, Wang, Bagel, Vite, Sikora, Hinderer, Calcedo, Yox, Steet, Ruane, ODonnell, Gao, Wilson, Casal, Ponder, Haskins: "Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 24, Issue 2, pp. 206-16, (2016) (PubMed).

Marcó, Pujol, Roca, Motas, Ribera, Garcia, Molas, Villacampa, Melia, Sánchez, Sánchez, Bertolin, Ruberte, Haurigot, Bosch: "Progressive neurologic and somatic disease in a novel mouse model of human mucopolysaccharidosis type IIIC." in: Disease models & mechanisms, Vol. 9, Issue 9, pp. 999-1013, (2016) (PubMed).

Liou, Wu, Liao, Chang, Chang, Shih: "A new animal model containing human SCARB2 and lacking stat-1 is highly susceptible to EV71." in: Scientific reports, Vol. 6, pp. 31151, (2016) (PubMed).

Kondo, Maksimova, Otomo, Kato, Imai, Asano, Kobayashi, Nojima, Nakaya, Hamada, Irahara, Gurinova, Sukhomyasova, Nogovicina, Savvina, Yoshimori, Ozono, Sakai: "Mutation in VPS33A affects metabolism of glycosaminoglycans: a new type of mucopolysaccharidosis with severe systemic symptoms." in: Human molecular genetics, Vol. 26, Issue 1, pp. 173-183, (2016) (PubMed).

Lobo, Arenas, Huerta, Sacristán, Pérez-Crespo, Gutiérrez-Adán, Díaz-Gil, Lasunción, Martín-Hidalgo: "Liver growth factor induces testicular regeneration in EDS-treated rats and increases protein levels of class B scavenger receptors." in: American journal of physiology. Endocrinology and metabolism, Vol. 308, Issue 2, pp. E111-21, (2015) (PubMed).

Mareninova, Sendler, Malla, Yakubov, French, Tokhtaeva, Vagin, Oorschot, Lüllmann-Rauch, Blanz, Dawson, Klumperman, Lerch, Mayerle, Gukovsky, Gukovskaya: "Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis." in: Cellular and molecular gastroenterology and hepatology, Vol. 1, Issue 6, pp. 678-694, (2015) (PubMed).

Synonyms and alternative names related to SCARB2

scavenger receptor class B, member 2a (scarb2a), scavenger receptor class B member 2 (SCARB2), scavenger receptor class B member 2 (scarb2), scavenger receptor class B, member 2 (Scarb2), 9330185J12Rik, AMRF, cd36l2, CD36L2, Cd36l2, chunp6914, EPM4, fi13c07, HLGP85, LGP85, LIMP-2, LIMPII, LimpII, MLGP85, SCARB2, scarb2, SR-BII, wu:fi13c07

Protein level used designations for SCARB2

  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2
  • CD36 antigen-like 2
  • lysosome membrane protein 2
  • scavenger receptor class B, member 2
  • lysosome membrane protein 2-like
  • putative lysosomal integral membrane protein II
  • 85 kDa lysosomal membrane sialoglycoprotein
  • 85 kDa lysosomal sialoglycoprotein scavenger receptor class B, member 2
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 2 (lysosomal integral membrane protein II)
  • LIMP II
  • lysosome membrane protein II
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