SAV1 Products
(Salvador Homolog 1 (SAV1))
Categories
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012].
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Featured SAV1 Categories
SAV1 Antibodies
High quality antibodies with extensive validation data.
SAV1 ELISA Kits
Reliable ELISA kits for a wide range of species.
SAV1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended SAV1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP
Validations
- (6)
- (6)
Cat. No.
ABIN566210
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (5)
Cat. No.
ABIN7166095
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP
Validations
- (5)
Cat. No.
ABIN7166096
Quantity
100 μL
Datasheet
Datasheet
Recommended SAV1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1152411
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1152412
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1152413
Quantity
96 tests
Datasheet
Datasheet
Recommended SAV1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319183
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095196
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136732
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our SAV1 products
: "Hippo pathway deficiency reverses systolic heart failure after infarction." in: Nature, Vol. 550, Issue 7675, pp. 260-264, (2018) (PubMed).: "Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway." in: The Journal of pathology, Vol. 239, Issue 1, pp. 97-108, (2016) (PubMed).
: "Hippo signaling mediates proliferation, invasiveness, and metastatic potential of clear cell renal cell carcinoma." in: Translational oncology, Vol. 7, Issue 2, pp. 309-21, (2014) (PubMed).
: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).
: "Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPAR?." in: PLoS ONE, Vol. 7, Issue 1, pp. e30983, (2012) (PubMed).
: "Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system." in: Molecular biology reports, Vol. 39, Issue 8, pp. 8225-30, (2012) (PubMed).
: "LATS2 is a tumor suppressor gene of malignant mesothelioma." in: Cancer research, Vol. 71, Issue 3, pp. 873-83, (2011) (PubMed).
: "Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions." in: The Journal of biological chemistry, Vol. 286, Issue 21, pp. 18483-91, (2011) (PubMed).
: "Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction." in: Nature cell biology, Vol. 12, Issue 12, pp. 1166-76, (2010) (PubMed).
: "Mutational analysis of salvador gene in human carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 111, Issue 6, pp. 595-8, (2003) (PubMed).
Synonyms and alternative names related to SAV1
salvador family WW domain containing protein 1 (SAV1), salvador family WW domain containing 1 (Sav1), salvador family WW domain containing protein 1 (Sav1), 1700040G09Rik, Salv, SAV, Sav, WW45, Wwp3, WWP4, Wwp4Protein level used designations for SAV1
- 1700040G09Rik
- 45 kDa WW domain protein
- WW domain-containing
- hWW45
- protein salvador homolog 1
- WW domain-containing protein 3
- WW domain-containing protein 4
- Salvador homolog 1 protein
- rWW45
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