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SARS-CoV-2 Spike S1 Products

(SARS-CoV-2 Spike S1)

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attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 receptor and internalization of the virus into the endosomes of the host cell induces conformational changes in the Spike glycoprotein (PubMed:32142651, PubMed:32075877, PubMed:32155444). Uses also human TMPRSS2 for priming in human lung cells which is an essential step for viral entry (PubMed:32142651). Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.

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Featured SARS-CoV-2 Spike S1 Categories

SARS-CoV-2 Spike S1 Antibodies

High quality antibodies with extensive validation data.

SARS-CoV-2 Spike S1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SARS-CoV-2 Spike S1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet

Application ELISA, IF, Crys, SPR, mIHC
Validations
  • (8)
  • (15)
  • (1)
Cat. No. ABIN6952546
Quantity 200 μg
Datasheet Datasheet
Reactivity SARS Coronavirus-2 (SARS-CoV-2)
Application ELISA, Neut
Validations
  • (7)
  • (10)
Cat. No. ABIN6952616
Quantity 100 μg
Datasheet Datasheet

Application ELISA, IF, Crys, SPR
Validations
  • (5)
  • (3)
Cat. No. ABIN6952547
Quantity 200 μg
Datasheet Datasheet

Recommended SARS-CoV-2 Spike S1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity SARS Coronavirus-2 (SARS-CoV-2)
Source HEK-293 Cells
Validations
  • (9)
  • (6)
Cat. No. ABIN6952427
Quantity 100 μg
Datasheet Datasheet
Reactivity SARS Coronavirus-2 (SARS-CoV-2)
Source Mammalian Cells
Validations
  • (5)
Cat. No. ABIN6953168
Quantity 1 mg
Datasheet Datasheet
Reactivity SARS Coronavirus-2 (SARS-CoV-2)
Source HEK-293 Cells
Validations
  • (4)
Cat. No. ABIN7274393
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our SARS-CoV-2 Spike S1 products

Erickson, Logsdon, Rhea, Hansen, Holden, Banks, Smith, German, Farr, Morley, Weaver, Hirsch, Kovac, Kontsekova, Baumann, Omer, Raber: "Blood-brain barrier penetration of non-replicating SARS-CoV-2 and S1 variants of concern induce neuroinflammation which is accentuated in a mouse model of Alzheimer's disease." in: Brain, behavior, and immunity, Vol. 109, pp. 251-268, (2023) (PubMed).

Fan, Parr, Kang, Gupta: "Point-of-care (POC) SARS-CoV-2 antigen detection using functionalized aerosol jet-printed organic electrochemical transistors (OECTs)." in: Nanoscale, Vol. 15, Issue 11, pp. 5476-5485, (2023) (PubMed).

Kannenberg, Trawinski, Henschler, Buhmann, Hönemann, Jassoy: "Antibody course and memory B-cell response in the first year after SARS-CoV-2 infection." in: The Journal of infectious diseases, (2022) (PubMed).

Xing, Dorey, Jayasinghe, Howorka: "Highly shape- and size-tunable membrane nanopores made with DNA." in: Nature nanotechnology, (2022) (PubMed).

Wu, Wu, Wang, Liu, Chu, Jiang, Kwong, Chow, Li, Chen: "Microfluidic particle dam for direct visualization of SARS-CoV-2 antibody levels in COVID-19 vaccinees." in: Science advances, Vol. 8, Issue 22, pp. eabn6064, (2022) (PubMed).

Jacobsen, Fabricius, Class, Topfstedt, Lorenzetti, Janowska, Schmidt, Staniek, Zernickel, Stamminger, Dietz, Zellmer, Hecht, Rauch, Blum, Ludwig, Jahrsdörfer, Schrezenmeier, Heeg, Mayer, Seidel, Groß et al.: "High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection. ..." in: Nature communications, Vol. 13, Issue 1, pp. 7315, (2022) (PubMed).

Kaneko, Satta, Komuro, Muthukrishnan, Kakarla, Guo, An, Elahi, Kornblum, Liebeskind, Hsiai, Hinman: "Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection." in: Stroke, Vol. 52, Issue 1, pp. 260-270, (2021) (PubMed).

Sasisekharan, Pentakota, Jayaraman, Tharakaraman, Wogan, Narayanasami: "Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 118, Issue 5, (2021) (PubMed).

Chouchane, Grivel, Farag, Pavlovski, Maacha, Sathappan, Al-Romaihi, Abuaqel, Ata, Ismail Chouchane, Remadi, Halabi, Rafii, Al-Thani, Marr, Subramanian, Shan: "Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2." in: JCI insight, (2021) (PubMed).

Dogan, Kozhaya, Placek, Gunter, Yigit, Hardy, Plassmeyer, Coatney, Lillard, Bukhari, Kleinberg, Hayes, Arditi, Klapper, Merin, Liang, Gupta, Alpan, Unutmaz: "SARS-CoV-2 specific antibody and neutralization assays reveal the wide range of the humoral immune response to virus." in: Communications biology, Vol. 4, Issue 1, pp. 129, (2021) (PubMed).

Synonyms and alternative names related to SARS-CoV-2 Spike S1

Surface Glycoprotein (S), E2

Protein level used designations for SARS-CoV-2 Spike S1

  • Peplomer protein
  • S Protein
  • S glycoprotein
  • S-Protein
  • Spike
  • Spike Protein
  • Spike glycoprotein
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