RUNX2 Products
(Runt-Related Transcription Factor 2 (RUNX2))
Categories
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2008].
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Featured RUNX2 Categories
RUNX2 Antibodies
High quality antibodies with extensive validation data.
RUNX2 ELISA Kits
Reliable ELISA kits for a wide range of species.
RUNX2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RUNX2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (2)
- (9)
Cat. No.
ABIN560185
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (5)
- (7)
Cat. No.
ABIN514045
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
- (12)
Cat. No.
ABIN3016834
Quantity
100 μL
Datasheet
Datasheet
Recommended RUNX2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN6959206
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
- (1)
Cat. No.
ABIN6959207
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969977
Quantity
96 tests
Datasheet
Datasheet
Recommended RUNX2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124937
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1318998
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1319000
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our RUNX2 products
: "The Toll-like receptor ligand, CpG oligodeoxynucleotides, regulate proliferation and osteogenic differentiation of osteoblast." in: Journal of orthopaedic surgery and research, Vol. 15, Issue 1, pp. 327, (2021) (PubMed).: "Human proximal tubular cells can form calcium phosphate deposits in osteogenic culture: role of cell death and osteoblast-like transdifferentiation." in: Cell death discovery, Vol. 5, pp. 57, (2019) (PubMed).
: "Growth Plate Borderline Chondrocytes Behave as Transient Mesenchymal Precursor Cells." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, (2019) (PubMed).
: "Role of RUNX2 transcription factor in epithelial mesenchymal transition in non-small cell lung cancer lung cancer: Epigenetic control of the RUNX2 P1 promoter." in: Tumour biology, Vol. 41, Issue 5, pp. 1010428319851014, (2019) (PubMed).
: "Silent Mating Type Information Regulation 2 Homolog (SIRT1) Influences Osteogenic Proliferation and Differentiation of MC3T3-E1 Cells via Regulation of miR-132-3p." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 25, pp. 2289-2295, (2019) (PubMed).
: "Rotator Cuff Tenocytes Differentiate into Hypertrophic Chondrocyte-Like Cells to Produce Calcium Deposits in an Alkaline Phosphatase-Dependent Manner." in: Journal of clinical medicine, Vol. 8, Issue 10, (2019) (PubMed).
: "Docosahexaenoic Acid (DHA) Inhibits Bone Morphogenetic Protein-2 (BMP-2) Elevated Osteoblast Potential of Metastatic Breast Cancer (MDA-MB-231) Cells in Mammary Microcalcification." in: Nutrition and cancer, pp. 1-11, (2019) (PubMed).
: "Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization." in: Nature communications, Vol. 10, Issue 1, pp. 3520, (2019) (PubMed).
: "Icaritin induces MC3T3-E1 subclone14 cell differentiation through estrogen receptor-mediated ERK1/2 and p38 signaling activation." in: Biomedicine & pharmacotherapy, Vol. 94, pp. 1-9, (2018) (PubMed).
: "mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis." in: Osteoarthritis and cartilage, Vol. 25, Issue 6, pp. 952-963, (2018) (PubMed).
Synonyms and alternative names related to RUNX2
runt related transcription factor 2 (RUNX2), runt-related transcription factor 2a (runx2a), runt related transcription factor 2 (Runx2), runt-related transcription factor 2 (Runx2), runt related transcription factor 2 (runx2), runt-related transcription factor 2 (LOC703331), runt-related transcription factor 2 (LOC100549663), runt related transcription factor 2 L homeolog (runx2.L), runt-related transcription factor 2 (RUNX2), AML3, aml3, Cbf, CBF-alpha-1, Cbfa-1, CBFA1, Cbfa1, cbfa1, CCD, ccd, CCD1, ccd1, CLCD, LS3, OSF-2, OSF2, Osf2, osf2, PEA2aA, pea2aa, Pebp2a1, pebp2a1, pebp2a2, PEBP2aA, pebp2aa, pebp2aa1, Pebpa2a, runx2, RUNX2Protein level used designations for RUNX2
- PEA2-alpha A
- PEBP2-alpha A
- SL3-3 enhancer factor 1 alpha A subunit
- SL3/AKV core-binding factor alpha A subunit
- acute myeloid leukemia 3 protein
- core-binding factor, runt domain, alpha subunit 1
- oncogene AML-3
- osteoblast-specific transcription factor 2
- polyomavirus enhancer-binding protein 2 alpha A subunit
- runt-related transcription factor 2
- transcription factor Runx2a
- AKV core binding factor
- CBF-alpha-1
- PEBP2 alpha A
- core binding factor alpha 1
- runt domain, alpha subunit 1
- core-binding factor subunit alpha-1
- runt related transcription factor 2
- transcription factor Cbfa1
- runt-related factor 2
- core binding factor alpha 1 subunit
- runt-related transcription factor 2-like
- Runx2 spliced isoform
- runt-related transcription factor 2 type I
- runt-related transcription factor 2 type II
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