RRM2B Products
(Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))
Categories
This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].
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Featured RRM2B Categories
RRM2B Antibodies
High quality antibodies with extensive validation data.
RRM2B ELISA Kits
Reliable ELISA kits for a wide range of species.
RRM2B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RRM2B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
- (2)
Cat. No.
ABIN565482
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (2)
Cat. No.
ABIN7168147
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6257482
Quantity
100 μL
Datasheet
Datasheet
Recommended RRM2B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969961
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951228
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1155811
Quantity
96 tests
Datasheet
Datasheet
Recommended RRM2B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1318906
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7317292
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3087246
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RRM2B products
: "Ribonucleotide reductase subunit M2B deficiency leads to mitochondrial permeability transition pore opening and is associated with aggressive clinicopathologic manifestations of breast cancer." in: American journal of translational research, Vol. 10, Issue 11, pp. 3635-3649, (2018) (PubMed).: "p53R2 regulates thioredoxin reductase activity through interaction with TrxR2." in: Biochemical and biophysical research communications, Vol. 482, Issue 4, pp. 706-712, (2016) (PubMed).
: "Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells." in: Oncotarget, Vol. 7, Issue 2, pp. 1984-99, (2016) (PubMed).
: "RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence." in: Scientific reports, Vol. 2, pp. 822, (2013) (PubMed).
: "Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer." in: Cancer research, Vol. 71, Issue 9, pp. 3202-13, (2011) (PubMed).
: "Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells." in: Biochemical and biophysical research communications, Vol. 410, Issue 1, pp. 102-7, (2011) (PubMed).
: "Ribonucleotide reductase small subunit p53R2 suppresses MEK-ERK activity by binding to ERK kinase 2." in: Oncogene, Vol. 28, Issue 21, pp. 2173-84, (2009) (PubMed).
: "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits." in: Cancer research, Vol. 63, Issue 5, pp. 980-6, (2003) (PubMed).
: "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells." in: The Journal of biological chemistry, Vol. 276, Issue 44, pp. 40647-51, (2001) (PubMed).
: "p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint." in: Cancer research, Vol. 61, Issue 22, pp. 8256-62, (2001) (PubMed).
Synonyms and alternative names related to RRM2B
ribonucleotide reductase M2 B (TP53 inducible) S homeolog (rrm2b.S), ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B), ribonucleotide reductase M2 B (TP53 inducible) (rrm2b), ribonucleotide reductase M2 B (TP53 inducible) (Rrm2b), ribonucleotide reductase regulatory TP53 inducible subunit M2B (Rrm2b), MTDPS8A, MTDPS8B, p53r2, P53R2, p53R2, RRM2BProtein level used designations for RRM2B
- ribonucleotide reductase M2 B (TP53 inducible)
- ribonucleoside-diphosphate reductase subunit M2 B
- TP53-inducible ribonucleotide reductase M2 B
- p53-inducible ribonucleotide reductase small subunit 2 homolog
- p53-inducible ribonucleotide reductase small subunit 2 short form beta
- p53-inducible ribonucleotide reductase small subunit 2-like protein
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