RPA1 Products
(Replication Protein A1, 70kDa (RPA1))
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Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair\; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange. Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.
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Featured RPA1 Categories
RPA1 Antibodies
High quality antibodies with extensive validation data.
RPA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
RPA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RPA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (1)
- (7)
Cat. No.
ABIN969564
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IP, IHC (p), ICC
Validations
- (7)
Cat. No.
ABIN2856633
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, FACS
Validations
- (7)
Cat. No.
ABIN1500741
Quantity
100 μL
Datasheet
Datasheet
Recommended RPA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959123
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6959124
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4972520
Quantity
96 tests
Datasheet
Datasheet
Recommended RPA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124825
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1318500
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7408951
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our RPA1 products
: "The nuclear DEK interactome supports multi-functionality." in: Proteins, Vol. 86, Issue 1, pp. 88-97, (2018) (PubMed).: "ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress." in: Cell, Vol. 158, Issue 3, pp. 633-46, (2014) (PubMed).
: "RPA coordinates DNA end resection and prevents formation of DNA hairpins." in: Molecular cell, Vol. 50, Issue 4, pp. 589-600, (2013) (PubMed).
: "MRX protects fork integrity at protein-DNA barriers, and its absence causes checkpoint activation dependent on chromatin context." in: Nucleic acids research, Vol. 41, Issue 5, pp. 3173-89, (2013) (PubMed).
: "Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy." in: Genes & cancer, Vol. 4, Issue 1-2, pp. 39-53, (2013) (PubMed).
: "Mechanism of release and fate of excised oligonucleotides during nucleotide excision repair." in: The Journal of biological chemistry, Vol. 287, Issue 27, pp. 22889-99, (2012) (PubMed).
: "In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signaling." in: The Journal of biological chemistry, Vol. 287, Issue 43, pp. 36123-31, (2012) (PubMed).
: "The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19237-46, (2011) (PubMed).
: "Role of interaction of XPF with RPA in nucleotide excision repair." in: Journal of molecular biology, Vol. 413, Issue 2, pp. 337-46, (2011) (PubMed).
: "Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation." in: Molecular and cellular biology, Vol. 30, Issue 6, pp. 1382-96, (2010) (PubMed).
Synonyms and alternative names related to RPA1
replication protein A1 (RPA1), replication protein A1 (Rpa1), replication protein A1 (rpa1), replication protein A1, 70kDa (RPA1), replication protein A1 L homeolog (rpa1.L), Replication Protein A 70 (RpA-70), 70kDa, 5031405K23Rik, AA589576, AW557552, Cb1-727, CG9633, D-RPA70, D-SSB, Dmel\\CG9633, DmRPA, dmrpa1, DRP-A, dRP-A, HSSB, hssb, i164, LOC100230990, MST075, mst075, REPA1, repa1, RF-A, rf-a, RP-A, rp-a, rpa, Rpa, RPA, Rpa-70, RPA1, RPA70, rpa70, RPA 70, RpA70, RPA 70 kDa, Ssb-70, wu:fi14b08, zgc:55337, zgc:77092Protein level used designations for RPA1
- MSTP075
- RF-A protein 1
- RP-A p70
- replication factor A protein 1
- replication protein A 70 kDa DNA-binding subunit
- single-stranded DNA-binding protein
- replication protein A1, 70kDa
- replication protein A1
- replication protein A 70 kDa DNA-binding subunit-like
- replication protein A (RPA)
- CG9633-PA
- RpA-70-PA
- drosophila replication protein A
- replication protein A 70
- single stranded-binding protein 70
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