ROCK1 Products
(rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
Categories
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008].
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Featured ROCK1 Categories
ROCK1 Antibodies
High quality antibodies with extensive validation data.
ROCK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
ROCK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ROCK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP, IF, IHC (p), ICC
Validations
- (1)
- (7)
Cat. No.
ABIN2856887
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
- (5)
Cat. No.
ABIN738636
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
- (4)
Cat. No.
ABIN562671
Quantity
100 μg
Datasheet
Datasheet
Recommended ROCK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971298
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN5608555
Quantity
96 tests
Datasheet
Datasheet
Recommended ROCK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124866
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1318431
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509131
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ROCK1 products
: "RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis†." in: Biology of reproduction, Vol. 100, Issue 3, pp. 711-720, (2019) (PubMed).: "Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation." in: Nature communications, Vol. 9, Issue 1, pp. 2049, (2019) (PubMed).
: "Comprehensive proteome analysis of human skeletal muscle in cachexia and sarcopenia: A pilot study." in: Journal of cachexia, sarcopenia and muscle, (2017) (PubMed).
: "RhoA/ROCK1 regulates Avian Reovirus S1133-induced switch from autophagy to apoptosis." in: BMC veterinary research, Vol. 11, pp. 103, (2015) (PubMed).
: "Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways." in: PLoS ONE, Vol. 10, Issue 8, pp. e0133699, (2015) (PubMed).
: "GM-CSF reduces expression of chondroitin sulfate proteoglycan (CSPG) core proteins in TGF-β-treated primary astrocytes." in: BMB reports, Vol. 47, Issue 12, pp. 679-84, (2015) (PubMed).
: "Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 3, pp. E384-93, (2014) (PubMed).
: "MiR-186 targets ROCK1 to suppress the growth and metastasis of NSCLC cells." in: Tumour biology, Vol. 35, Issue 9, pp. 8933-7, (2014) (PubMed).
: "miR-124 inhibits growth and invasion of gastric cancer by targeting ROCK1." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 15, Issue 16, pp. 6543-6, (2014) (PubMed).
: "Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway." in: The international journal of biochemistry & cell biology, Vol. 45, Issue 7, pp. 1447-56, (2013) (PubMed).
Synonyms and alternative names related to ROCK1
Rho associated coiled-coil containing protein kinase 1 (ROCK1), Rho kinase (Rok), Rho-associated coiled-coil containing protein kinase 1 (Rock1), Rho-associated, coiled-coil containing protein kinase 1 (rock1), 1110055K06Rik, CG9774, Dmel\\CG9774, DRhk, DROK, DRok, Drok, dROK, dRok, drok, LOC100229794, P160Rock, P160ROCK, p160ROCK, Rhk, RhoK, ROCK, Rock, ROCK-1, Rock-I, ROCK-I, ROCK1, ROK, Rok, ROKalpha/betaProtein level used designations for ROCK1
- Rho-associated coiled coil containing protein kinase 1
- rho-associated protein kinase 1
- Rho-associated, coiled-coil containing protein kinase 1
- CG9774-PA
- DRho-kinase
- ROCK
- Rho-associated kinase
- RhoA kinase
- drosophila rho-associated kinase
- rho kinase
- rok-PA
- Rho-associated coiled-coil forming kinase 1
- p160 ROCK-1
- p160ROCK
- rho-associated, coiled-coil-containing protein kinase 1
- rho-associated, coiled-coil-containing protein kinase I
- Rho-associated kinase beta
- liver regeneration-related protein LRRG199
- p150 RhoA-binding kinase ROK beta
- Rho kinase
- p160-ROCK
- renal carcinoma antigen NY-REN-35
- HEBM1
- cAMP-dependent protein kinase ROCK-I
- cePKA
- corneal epithelial Rho-associated-Ser/Thr kinase 1
- Rho-kinase beta
- Rho-associated protein kinase 1
- rho-associated coiled-coil domain-containing protein kinase 1
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