RNF139 Products
(Ring Finger Protein 139 (RNF139))
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The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008].
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RNF139 Antibodies
High quality antibodies with extensive validation data.
RNF139 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RNF139 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (4)
Cat. No.
ABIN564887
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Cow, Dog, Guinea Pig, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN6749727
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7151154
Quantity
100 μL
Datasheet
Datasheet
Recommended RNF139 Proteins
Latest Publications for our RNF139 products
: "TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 for ubiquitination and degradation." in: Oncogene, Vol. 32, Issue 18, pp. 2325-34, (2013) (PubMed).: "A meckelin-filamin A interaction mediates ciliogenesis." in: Human molecular genetics, Vol. 21, Issue 6, pp. 1272-86, (2012) (PubMed).
: "The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways." in: Molecular cancer research : MCR, Vol. 8, Issue 1, pp. 93-106, (2010) (PubMed).
: "The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces ..." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28995-9004, (2009) (PubMed).
: "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER." in: The Journal of cell biology, Vol. 186, Issue 5, pp. 685-92, (2009) (PubMed).
: "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene." in: Oncogene, Vol. 26, Issue 16, pp. 2263-71, (2007) (PubMed).
Synonyms and alternative names related to RNF139
ring finger protein 139 (RNF139), ring finger protein 139 (Rnf139), ring finger protein 139 (rnf139), ring finger protein 139 S homeolog (rnf139.S), 4930555P18Rik, HRCA1, RCA1, rnf139, TRC8, zgc:175173Protein level used designations for RNF139
- E3 ubiquitin-protein ligase RNF139
- multiple membrane spanning receptor TRC8
- patched related protein translocated in renal cancer
- translocation in renal carcinoma on chromosome 8 protein
- RING finger protein 139
- ring finger protein 139 S homeolog
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