RNF111 Products
(Ring Finger Protein 111 (RNF111))
Categories
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
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Featured RNF111 Categories
RNF111 Antibodies
High quality antibodies with extensive validation data.
RNF111 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RNF111 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, RNAi
Validations
- (9)
- (5)
Cat. No.
ABIN527194
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
- (3)
Cat. No.
ABIN527193
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (2)
Cat. No.
ABIN6257485
Quantity
100 μL
Datasheet
Datasheet
Recommended RNF111 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1318194
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095070
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136968
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RNF111 products
: "The Arkadia-ESRP2 axis suppresses tumor progression: analyses in clear-cell renal cell carcinoma." in: Oncogene, Vol. 35, Issue 27, pp. 3514-23, (2016) (PubMed).: "SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair." in: Nature communications, Vol. 6, pp. 7499, (2015) (PubMed).
: "Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-? signalling." in: Nature communications, Vol. 5, pp. 3388, (2014) (PubMed).
: "Multiple Arkadia/RNF111 structures coordinate its Polycomb body association and transcriptional control." in: Molecular and cellular biology, Vol. 34, Issue 16, pp. 2981-95, (2014) (PubMed).
: "RNF111-dependent neddylation activates DNA damage-induced ubiquitination." in: Molecular cell, Vol. 49, Issue 5, pp. 897-907, (2013) (PubMed).
: "Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation." in: Molecular and cellular biology, Vol. 33, Issue 11, pp. 2163-77, (2013) (PubMed).
: "RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response." in: The Journal of cell biology, Vol. 201, Issue 6, pp. 797-807, (2013) (PubMed).
: "Efficient TGF-?/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression." in: Molecular cancer, Vol. 10, Issue 1, pp. 2, (2011) (PubMed).
: "RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity." in: The Journal of biological chemistry, Vol. 286, Issue 37, pp. 32502-12, (2011) (PubMed).
: "Context-dependent regulation of the expression of c-Ski protein by Arkadia in human cancer cells." in: Journal of biochemistry, Vol. 147, Issue 4, pp. 545-54, (2010) (PubMed).
Synonyms and alternative names related to RNF111
ring finger protein 111 (RNF111), ring finger 111 (Rnf111), ring finger protein 111 (Rnf111), ring finger protein 111 (rnf111-b), ring finger protein 111 (rnf111), ARK, ark, Arkadia, MGC81253, MGC146379, RNF111, rnf111Protein level used designations for RNF111
- Arkadia
- E3 ubiquitin-protein ligase Arkadia
- RING finger protein 111
- ring finger 111
- arkadia
- ring finger protein 111
- E3 ubiquitin-protein ligase arkadia-B
- RING finger protein 111-B
- e3 ubiquitin-protein ligase Arkadia-like
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