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RNASEL Products

(Ribonuclease L (2',5'-Oligoisoadenylate Synthetase-Dependent) (RNASEL))
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008].

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Featured RNASEL Categories

RNASEL Antibodies

High quality antibodies with extensive validation data.

RNASEL ELISA Kits

Reliable ELISA kits for a wide range of species.

RNASEL Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RNASEL Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB
Validations
  • (4)
Cat. No. ABIN6146994
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC
Validations
  • (3)
Cat. No. ABIN7264894
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7435379
Quantity 100 μL
Datasheet Datasheet

Recommended RNASEL ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6959174
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN5658504
Quantity 96 tests
Datasheet Datasheet

Recommended RNASEL Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318166
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7402817
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7397231
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our RNASEL products

Fabre, Salehzada, Lambert, Boo Seok, Zhou, Mercier, Bisbal: "RNase L controls terminal adipocyte differentiation, lipids storage and insulin sensitivity via CHOP10 mRNA regulation." in: Cell death and differentiation, Vol. 19, Issue 9, pp. 1470-81, (2012) (PubMed).

Al-Haj, Blackshear, Khabar: "Regulation of p21/CIP1/WAF-1 mediated cell-cycle arrest by RNase L and tristetraprolin, and involvement of AU-rich elements." in: Nucleic acids research, Vol. 40, Issue 16, pp. 7739-52, (2012) (PubMed).

Al-Ahmadi, Al-Ghamdi, Al-Haj, Al-Saif, Khabar: "Alternative polyadenylation variants of the RNA binding protein, HuR: abundance, role of AU-rich elements and auto-Regulation." in: Nucleic acids research, Vol. 37, Issue 11, pp. 3612-24, (2009) (PubMed).

Lin, Yu, Chang, Tang, Liao, Lin: "Distinct antiviral roles for human 2',5'-oligoadenylate synthetase family members against dengue virus infection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 12, pp. 8035-43, (2009) (PubMed).

Han, Townsend, Jha, Paranjape, Silverman, Barton: "A phylogenetically conserved RNA structure in the poliovirus open reading frame inhibits the antiviral endoribonuclease RNase L." in: Journal of virology, Vol. 81, Issue 11, pp. 5561-72, (2007) (PubMed).

Carpten, Nupponen, Isaacs, Sood, Robbins, Xu, Faruque, Moses, Ewing, Gillanders, Hu, Bujnovszky, Makalowska, Baffoe-Bonnie, Faith, Smith, Stephan, Wiley, Brownstein, Gildea, Kelly, Jenkins, Hostetter et al.: "Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. ..." in: Nature genetics, Vol. 30, Issue 2, pp. 181-4, (2002) (PubMed).

Wang, Zhou, Vasavada, Dong, Nie, Church, Williams, Banerjee, Silverman: "Elevated levels of 2',5'-linked oligoadenylate-dependent ribonuclease L occur as an early event in colorectal tumorigenesis." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 1, Issue 11, pp. 1421-8, (1999) (PubMed).

Dong, Silverman: "A bipartite model of 2-5A-dependent RNase L." in: The Journal of biological chemistry, Vol. 272, Issue 35, pp. 22236-42, (1997) (PubMed).

Dong, Silverman: "2-5A-dependent RNase molecules dimerize during activation by 2-5A." in: The Journal of biological chemistry, Vol. 270, Issue 8, pp. 4133-7, (1995) (PubMed).

Synonyms and alternative names related to RNASEL

ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) (Rnasel), ribonuclease L (RNASEL), E230029I04Rik, PRCA1, RNS4

Protein level used designations for RNASEL

  • 2-5A-dependent RNAase
  • 2-5A-dependent RNase
  • 2-5A-dependent ribonuclease
  • RNase L
  • ribonuclease 4
  • 2',5'-oligoisoadenylate synthetase-dependent
  • interferon-induced 2-5A-dependent RNase
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