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RNASEH2A Products

(Ribonuclease H2, Subunit A (RNASEH2A))

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The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].

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Featured RNASEH2A Categories

RNASEH2A Antibodies

High quality antibodies with extensive validation data.

RNASEH2A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RNASEH2A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, RNAi
Validations
  • (5)
Cat. No. ABIN564592
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (5)
Cat. No. ABIN523945
Quantity 50 μg
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7445717
Quantity 100 μL
Datasheet Datasheet

Recommended RNASEH2A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6210762
Quantity 96 tests
Datasheet Datasheet

Recommended RNASEH2A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1318161
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419391
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7419394
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our RNASEH2A products

Zimmermann, Murina, Reijns, Agathanggelou, Challis, Tarnauskaitė, Muir, Fluteau, Aregger, McEwan, Yuan, Clarke, Lambros, Paneesha, Moss, Chandrashekhar, Angers, Moffat, Brunton, Hart, de Bono et al.: "CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. ..." in: Nature, Vol. 559, Issue 7713, pp. 285-289, (2019) (PubMed).

Wang, Wang, Feng, Shepherd, Zhang, Tang, Chen, Srivastava, McLaughlin, Navone, Hart, Chen: "Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition." in: Oncogene, (2018) (PubMed).

Bartsch, Damme, Regen, Becker, Garrett, Hölter, Knittler, Borowski, Waisman, Glatzel, Fuchs, Gailus-Durner, Hrabe de Angelis, Rabe: "RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation." in: Frontiers in immunology, Vol. 9, pp. 587, (2018) (PubMed).

Tresini, Warmerdam, Kolovos, Snijder, Vrouwe, Demmers, van IJcken, Grosveld, Medema, Hoeijmakers, Mullenders, Vermeulen, Marteijn: "The core spliceosome as target and effector of non-canonical ATM signalling." in: Nature, Vol. 523, Issue 7558, pp. 53-8, (2015) (PubMed).

Cuadrado, Michailidou, van Bodegraven, Jansen, Sluijs, Geerts, Couraud, De Filippis, Vescovi, Kuijpers, Hol: "Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3623-33, (2015) (PubMed).

Synonyms and alternative names related to RNASEH2A

ribonuclease H2 subunit A (rnaseh2a), ribonuclease H2 subunit A (RNASEH2A), ribonuclease H2, large subunit (Rnaseh2a), ribonuclease H2, subunit A (rnaseh2a), ribonuclease H2 subunit A L homeolog (rnaseh2a.L), ribonuclease H2, subunit A (RNASEH2A), ribonuclease H2, subunit A (Rnaseh2a), 2400006P09Rik, AGS4, JUNB, RNASEHI, RNHIA, RNHL, zgc:56307

Protein level used designations for RNASEH2A

  • ribonuclease H2, large subunit
  • ribonuclease HI, large subunit
  • RNase H2 subunit A
  • RNase HI large subunit
  • ribonuclease H2 subunit A
  • ribonuclease HI large subunit
  • ribonuclease HI subunit A
  • RNase H(35)
  • aicardi-Goutieres syndrome 4 protein
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