RNASEH2A Products
(Ribonuclease H2, Subunit A (RNASEH2A))
Categories
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009].
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Featured RNASEH2A Categories
RNASEH2A Antibodies
High quality antibodies with extensive validation data.
RNASEH2A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RNASEH2A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, RNAi
Validations
- (5)
Cat. No.
ABIN564592
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (5)
Cat. No.
ABIN523945
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7445717
Quantity
100 μL
Datasheet
Datasheet
Recommended RNASEH2A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6210762
Quantity
96 tests
Datasheet
Datasheet
Recommended RNASEH2A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1318161
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419391
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7419394
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our RNASEH2A products
: "CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. ..." in: Nature, Vol. 559, Issue 7713, pp. 285-289, (2019) (PubMed).: "Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition." in: Oncogene, (2018) (PubMed).
: "RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation." in: Frontiers in immunology, Vol. 9, pp. 587, (2018) (PubMed).
: "The core spliceosome as target and effector of non-canonical ATM signalling." in: Nature, Vol. 523, Issue 7558, pp. 53-8, (2015) (PubMed).
: "Phenotypic variation in Aicardi-Goutières syndrome explained by cell-specific IFN-stimulated gene response and cytokine release." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3623-33, (2015) (PubMed).
Synonyms and alternative names related to RNASEH2A
ribonuclease H2 subunit A (rnaseh2a), ribonuclease H2 subunit A (RNASEH2A), ribonuclease H2, large subunit (Rnaseh2a), ribonuclease H2, subunit A (rnaseh2a), ribonuclease H2 subunit A L homeolog (rnaseh2a.L), ribonuclease H2, subunit A (RNASEH2A), ribonuclease H2, subunit A (Rnaseh2a), 2400006P09Rik, AGS4, JUNB, RNASEHI, RNHIA, RNHL, zgc:56307Protein level used designations for RNASEH2A
- ribonuclease H2, large subunit
- ribonuclease HI, large subunit
- RNase H2 subunit A
- RNase HI large subunit
- ribonuclease H2 subunit A
- ribonuclease HI large subunit
- ribonuclease HI subunit A
- RNase H(35)
- aicardi-Goutieres syndrome 4 protein
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