RIPK1 Products
(Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
Categories
Serine-threonine kinase which transduces inflammatory and cell-death signals (necroptosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necroptosis-inducing complex.
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Featured RIPK1 Categories
RIPK1 Antibodies
High quality antibodies with extensive validation data.
RIPK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
RIPK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RIPK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7441202
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7441205
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (8)
Cat. No.
ABIN1490909
Quantity
100 μL
Datasheet
Datasheet
Recommended RIPK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6959056
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969845
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969846
Quantity
96 tests
Datasheet
Datasheet
Recommended RIPK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (2)
- (1)
Cat. No.
ABIN1318108
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124799
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1318110
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our RIPK1 products
: "Isolation and characterization of cluster of differentiation 9-positive ependymal cells as potential adult neural stem/progenitor cells in the third ventricle of adult rats." in: Cell and tissue research, Vol. 379, Issue 3, pp. 497-509, (2020) (PubMed).: "Modulation of lung cancer cell plasticity and heterogeneity with the restoration of cisplatin sensitivity by neurotensin antibody." in: Cancer letters, Vol. 444, pp. 147-161, (2019) (PubMed).
: "Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis." in: Frontiers in molecular neuroscience, Vol. 12, pp. 222, (2019) (PubMed).
: "Necroptosis in pulmonary macrophages mediates lipopolysaccharide-induced lung inflammatory injury by activating ZBP-1." in: International immunopharmacology, Vol. 77, pp. 105944, (2019) (PubMed).
: "Transcription modulation by CDK9 regulates inflammatory genes and RIPK3-MLKL-mediated necroptosis in periodontitis progression." in: Scientific reports, Vol. 9, Issue 1, pp. 17369, (2019) (PubMed).
: "TDP-43 accelerates age-dependent degeneration of interneurons." in: Scientific reports, Vol. 7, Issue 1, pp. 14972, (2018) (PubMed).
: "Targeting necroptotic cell death pathway by high-intensity interval training (HIIT) decreases development of post-ischemic adverse remodelling after myocardial ischemia / reperfusion injury." in: Journal of cell communication and signaling, (2018) (PubMed).
: "Vascular peroxide 1 promotes ox-LDL-induced programmed necrosis in endothelial cells through a mechanism involving β-catenin signaling." in: Atherosclerosis, Vol. 274, pp. 128-138, (2018) (PubMed).
: "Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors." in: BMC cancer, Vol. 16, pp. 545, (2017) (PubMed).
: "Tubular epithelial cells in renal clear cell carcinoma express high RIPK1/3 and show increased susceptibility to TNF receptor 1-induced necroptosis." in: Cell death & disease, Vol. 7, Issue 6, pp. e2287, (2016) (PubMed).
Synonyms and alternative names related to RIPK1
receptor interacting serine/threonine kinase 1 (RIPK1), receptor (TNFRSF)-interacting serine-threonine kinase 1 (Ripk1), receptor interacting serine/threonine kinase 1 (Ripk1), receptor interacting serine/threonine kinase 1 L homeolog (ripk1.L), D330015H01Rik, Rinp, RIP, RIP1, Rip1, rip1, ripk1, xrip1, xRIP1betaProtein level used designations for RIPK1
- RIP-1
- cell death protein RIP
- receptor interacting protein
- receptor-interacting protein 1
- receptor-interacting serine/threonine-protein kinase 1
- serine/threonine-protein kinase RIP
- receptor (TNFRSF)-interacting serine-threonine kinase 1
- receptor interacting serine/threonine kinase 1 L homeolog
- receptor-interacting protein 1 beta
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