RIKEN cDNA 4930404A10 Gene Products
(RIKEN cDNA 4930404A10 Gene (4930404A10RIK))
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Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase- mediated cleavage. Acts by facilitating kinetochore mono- orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis. {ECO:0000269|PubMed:25533956}.
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RIKEN cDNA 4930404A10 Gene Antibodies
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Recommended RIKEN cDNA 4930404A10 Gene Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3083500
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3122457
Quantity
1 mg
Datasheet
Datasheet
Synonyms and alternative names related to RIKEN cDNA 4930404A10 Gene
meiotic kinetochore factor (Meikin), 4930404A10RikProtein level used designations for RIKEN cDNA 4930404A10 Gene
- meiosis-specific kinetochore protein
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