RFX5 Products
(Regulatory Factor X 5 (RFX5))
Categories
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS\; MIM 209920). At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995). RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq, Jul 2008].
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Featured RFX5 Categories
RFX5 Antibodies
High quality antibodies with extensive validation data.
RFX5 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RFX5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, GS
Validations
- (3)
- (2)
Cat. No.
ABIN106544
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN948403
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7150384
Quantity
100 μL
Datasheet
Datasheet
Recommended RFX5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6207337
Quantity
96 tests
Datasheet
Datasheet
Recommended RFX5 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317888
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317890
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2730796
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our RFX5 products
: "Increased error-free DNA repair gene expression through reprogramming in human iPS cells." in: Regenerative therapy, Vol. 11, pp. 101-105, (2019) (PubMed).: "The transcription factor RFX5 is a transcriptional activator of the TPP1 gene in hepatocellular carcinoma." in: Oncology reports, Vol. 37, Issue 1, pp. 289-296, (2017) (PubMed).
: "Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III." in: PLoS ONE, Vol. 11, Issue 2, pp. e0148753, (2016) (PubMed).
: "In contrast to Chlamydia trachomatis, Waddlia chondrophila grows in human cells without inhibiting apoptosis, fragmenting the Golgi apparatus, or diverting post-Golgi sphingomyelin transport." in: Infection and immunity, Vol. 83, Issue 8, pp. 3268-80, (2015) (PubMed).
: "PML promotes MHC class II gene expression by stabilizing the class II transactivator." in: The Journal of cell biology, Vol. 199, Issue 1, pp. 49-63, (2012) (PubMed).
: "HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells." in: Journal of molecular and cellular cardiology, Vol. 46, Issue 3, pp. 292-9, (2009) (PubMed).
: "Identifying catalytic residues in CPAF, a Chlamydia-secreted protease." in: Archives of biochemistry and biophysics, Vol. 485, Issue 1, pp. 16-23, (2009) (PubMed).
: "Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression." in: The Journal of biological chemistry, Vol. 281, Issue 14, pp. 9260-70, (2006) (PubMed).
Synonyms and alternative names related to RFX5
regulatory factor X5 (RFX5), regulatory factor X, 5 (influences HLA class II expression) (Rfx5), regulatory factor X5 (Rfx5)Protein level used designations for RFX5
- DNA-binding protein RFX5
- regulatory factor X 5
- DNA-binding protein Rfx5
- regulatory factor X, 5
- regulator factor X 5
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