Obesity Research Tools and Pathways: Handbook
Julian PampelObesity, a condition often associated with metabolic diseases, has its roots in the fundamental biological functions of body fat. Body fat, or adipose tissue, originally evolved to play a critical role in energy storage, protecting delicate organs, and regulating reproduction through complex hormonal signals. In vertebrates, specialized cells known as adipocytes are responsible for storing energy in the form of lipid droplets. However, despite its important role, excess body fat can lead to severe health issues, including cardiovascular diseases, and an increased risk of certain cancers and type 2 diabetes. This overview covers the various factors that contribute to obesity as well as the research tools available for studying these pathways. Download our handbook or take a look at highlighted chapters down below first!
Obesity Handbook Highlights
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Glucagon, GLP-1, and the Obesity Pandemic
This chapter explores the role of glucagon and glucagon-like peptide-1 in obesity and metabolic regulation. It highlights their dual functions in blood glucose control and appetite regulation, which make them promising targets for therapeutic intervention in obesity and diabetes. -
Adipocyte Differentiation & Function
Adipocytes play a central role in energy storage and metabolism. This chapter delves into the molecular pathways that govern adipocyte differentiation, function, and dysfunction in obesity. Key markers and signaling proteins associated with adipogenesis are discussed, along with reagents and assays to study adipocyte biology. -
Chronic inflammation & Inflammatory Markers
Obesity is often accompanied by low-grade chronic inflammation. This chapter focuses on inflammatory cytokines, chemokines, and immune cell markers implicated in obesity and its complications. The section also discusses how to measure these markers using antibodies and assay kits to better understand the link between inflammation and metabolic diseases. -
Lipid Metabolism Enzymes
Lipid metabolism is a cornerstone of obesity research. This chapter provides an overview of key enzymes involved in lipogenesis, lipolysis, and lipid storage. It also showcases specific tools, including ELISA kits and activity assays, for studying lipid-related pathways in the context of obesity and related disorders.
This handbook is a collaborative effort between Rockland and antibodies-online, two companies united in their commitment to advancing scientific research. Together, we have developed a comprehensive resource, offering a suite of high-quality products specifically designed to facilitate the study of obesity-related mechanisms. By combining Rockland’s expertise in assay development and antibodies-online’s extensive catalog of research tools, this guide aims to empower researchers to explore the complexities of obesity and its associated diseases with cutting-edge solutions.
