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Retinoblastoma 1 Products

(Retinoblastoma 1 (RB1))

Categories

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008].

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Featured Retinoblastoma 1 Categories

Retinoblastoma 1 Antibodies

High quality antibodies with extensive validation data.

Retinoblastoma 1 ELISA Kits

Reliable ELISA kits for a wide range of species.

Retinoblastoma 1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Retinoblastoma 1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro)
Validations
  • (1)
  • (1)
Cat. No. ABIN675294
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN712946
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (1)
  • (3)
Cat. No. ABIN6264703
Quantity 100 μL
Datasheet Datasheet

Recommended Retinoblastoma 1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (5)
Cat. No. ABIN6574260
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
Cat. No. ABIN5526749
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6969918
Quantity 96 tests
Datasheet Datasheet

Recommended Retinoblastoma 1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1317543
Quantity 10 μg
Datasheet Datasheet
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7505541
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7393433
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Retinoblastoma 1 products

Ma, Jiang, Zhang, Ding, Xu, Lu: "IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1445-1450, (2018) (PubMed).

Béguelin, Rivas, Calvo Fernández, Teater, Purwada, Redmond, Shen, Challman, Elemento, Singh, Melnick: "EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop." in: Nature communications, Vol. 8, Issue 1, pp. 877, (2018) (PubMed).

Huang, Xu, Zhang, Ma, Guo, Wang, Zhang, Gou, Chen, Liang, Cao: "ICAM-1-Targeted Liposomes Loaded with Liver X Receptor Agonists Suppress PDGF-Induced Proliferation of Vascular Smooth Muscle Cells." in: Nanoscale research letters, Vol. 12, Issue 1, pp. 322, (2017) (PubMed).

Qin, Zheng, Zhou, Ou, Huang, Yan, Qin, Yang, Su, Bai, Guo, Lin: "Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins." in: Scientific reports, Vol. 6, pp. 19587, (2017) (PubMed).

Wu, Fu, Liu, Li, Huang, Xue, Xu, Sun, Zhao, Mi: "Cell proliferation downregulated by TGF-β2-triggered G1/S checkpoint in clinical CAFs." in: Cell cycle (Georgetown, Tex.), Vol. 16, Issue 2, pp. 172-178, (2017) (PubMed).

Tan, Wu, Ren, Wang, Li, Alshenawy, Li, Cui, Luo, Siegel, Fu, Lu: "A Point Mutation in DNA Polymerase β (POLB) Gene Is Associated with Increased Progesterone Receptor (PR) Expression and Intraperitoneal Metastasis in Gastric Cancer." in: Journal of Cancer, Vol. 7, Issue 11, pp. 1472-80, (2016) (PubMed).

Jie, Weilong, Ming, Fei, Xinghua, Junhua, Guobin, Kaixiong, Xiaoming: "Enhancer of zeste homolog 2 depletion induces cellular senescence via histone demethylation along the INK4/ARF locus." in: The international journal of biochemistry & cell biology, Vol. 65, pp. 104-12, (2016) (PubMed).

Zhang, Sun, Ye, Ashraf, Chen, Zhu, He, Xu, Wei, Chen, Fu, Liu, Cao: "Quantitative Label-Free Phosphoproteomics Reveals Differentially Regulated Protein Phosphorylation Involved in West Nile Virus-Induced Host Inflammatory Response." in: Journal of proteome research, Vol. 14, Issue 12, pp. 5157-68, (2016) (PubMed).

Iwahori, Hakki, Chou, Kalejta: "Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97." in: The Journal of biological chemistry, Vol. 290, Issue 32, pp. 19666-80, (2015) (PubMed).

Wu, Lv, He, Zhang, Mei, Cui, Huang, Xie, Xu, Zhang: "MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes." in: Cell communication and signaling : CCS, Vol. 12, pp. 66, (2015) (PubMed).

Synonyms and alternative names related to Retinoblastoma 1

RB transcriptional corepressor 1 (RB1), RB transcriptional corepressor like 1 (RBL1), RB transcriptional corepressor 1 (Rb1), RB transcriptional corepressor 1 (rb1), retinoblastoma 1 (rb1), OSRC, p105-Rb, P105-RB, pp110, PP110, pRb, RB, Rb, Rb-1, RB11, zgc:154147

Protein level used designations for Retinoblastoma 1

  • retinoblastoma suspectibility protein
  • retinoblastoma-associated protein
  • retinoblastoma-like protein 1
  • pp105
  • Retinoblastoma 1 (including osteosarcoma)
  • pRb
  • rb
  • retinoblastoma 1 (including osteosarcoma)
  • retinoblastoma protein
  • retinoblastoma, susceptibility
  • Retinoblastoma-associated protein
  • retinoblastoma 1
  • retinoblastoma-associated protein-like
  • spc
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