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RELB Products

(V-Rel Reticuloendotheliosis Viral Oncogene Homolog B (RELB))

Categories

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF- kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. Stimulates promoter activity in the presence of p49- and p50-NF-kappa-B. Neither associates with DNA nor with p65-NF-kappa-B (By similarity).

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Featured RELB Categories

RELB Antibodies

High quality antibodies with extensive validation data.

RELB ELISA Kits

Reliable ELISA kits for a wide range of species.

RELB Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RELB Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, PLA
Validations
  • (2)
  • (1)
Cat. No. ABIN519730
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
  • (1)
Cat. No. ABIN948396
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IP, IHC (p), ChIP
Validations
  • (5)
Cat. No. ABIN2855360
Quantity 100 μL
Datasheet Datasheet

Recommended RELB ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971106
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960423
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative DNA-Binding ELISA
Validations
  • (2)
Cat. No. ABIN5690758
Quantity 96 tests
Datasheet Datasheet

Recommended RELB Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1317787
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7394939
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7405328
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our RELB products

Ta, Schwensen, Liuwantara, Huso, Watnick, Rangan: "Constitutive renal Rel/nuclear factor-κB expression in Lewis polycystic kidney disease rats." in: World journal of nephrology, Vol. 5, Issue 4, pp. 339-57, (2016) (PubMed).

Pyz, Naidenko, Miyake, Yamamura, Berberich, Cardell, Kronenberg, Herrmann: "The complementarity determining region 2 of BV8S2 (V beta 8.2) contributes to antigen recognition by rat invariant NKT cell TCR." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7447-55, (2006) (PubMed).

Kaetzel: "The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces." in: Immunological reviews, Vol. 206, pp. 83-99, (2005) (PubMed).

Marienfeld, Berberich-Siebelt, Berberich, Denk, Serfling, Neumann: "Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-kappaB control." in: Oncogene, Vol. 20, Issue 56, pp. 8142-7, (2002) (PubMed).

Synonyms and alternative names related to RELB

avian reticuloendotheliosis viral (v-rel) oncogene related B (Relb), RELB proto-oncogene, NF-kB subunit (RELB), RELB proto-oncogene, NF-kB subunit (Relb), v-rel avian reticuloendotheliosis viral oncogene homolog B S homeolog (relb.S), GC-rich, I-REL, IREL, REL-B, relb-A, shep, XRelB

Protein level used designations for RELB

  • transcription factor RelB
  • v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
  • v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
  • avian reticuloendotheliosis viral (v-rel) oncogene related B
  • v-rel reticuloendotheliosis viral oncogene homolog B
  • transcription factor RelB homolog
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