RECQL2 Products
(Werner syndrome RecQ like helicase (WRN))
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This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging. [provided by RefSeq, Jul 2008].
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Featured RECQL2 Categories
RECQL2 Antibodies
High quality antibodies with extensive validation data.
Recommended RECQL2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN656017
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
Cat. No.
ABIN521400
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6266052
Quantity
100 μL
Datasheet
Datasheet
Recommended RECQL2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6222562
Quantity
96 tests
Datasheet
Datasheet
Recommended RECQL2 Proteins
Latest Publications for our RECQL2 products
: "Successful Cord Blood Transplantation in a Werner Syndrome Patient with High-risk Myelodysplastic Syndrome." in: Internal medicine (Tokyo, Japan), Vol. 58, Issue 1, pp. 109-113, (2019) (PubMed).: "WRN helicase is a synthetic lethal target in microsatellite unstable cancers. ..." in: Nature, Vol. 568, Issue 7753, pp. 551-556, (2019) (PubMed).
: "miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment." in: Molecular carcinogenesis, Vol. 57, Issue 2, pp. 295-302, (2018) (PubMed).
: "CDK1 phosphorylates WRN at collapsed replication forks." in: Nature communications, Vol. 7, pp. 12880, (2016) (PubMed).
: "DNA2 drives processing and restart of reversed replication forks in human cells." in: The Journal of cell biology, Vol. 208, Issue 5, pp. 545-62, (2015) (PubMed).
: "WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome." in: Virchows Archiv : an international journal of pathology, Vol. 466, Issue 3, pp. 343-50, (2015) (PubMed).
: "The Werner syndrome protein limits the error-prone 8-oxo-dG lesion bypass activity of human DNA polymerase kappa." in: Nucleic acids research, Vol. 42, Issue 19, pp. 12027-40, (2014) (PubMed).
: "Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress." in: Nucleic acids research, Vol. 42, Issue 20, pp. 12628-39, (2014) (PubMed).
: "Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling." in: DNA repair, Vol. 12, Issue 2, pp. 128-39, (2013) (PubMed).
: "Identification and characterization of SMARCAL1 protein complexes." in: PLoS ONE, Vol. 8, Issue 5, pp. e63149, (2013) (PubMed).
Synonyms and alternative names related to RECQL2
Werner syndrome RecQ like helicase (WRN), mediator of RNA polymerase II transcription subunit 34 (LOC9327212), Bloom syndrome RecQ like helicase (blm), Werner syndrome RecQ like helicase (Wrn), Werner syndrome, RecQ helicase-like L homeolog (wrn.L), AI846146, ffa-1, recq2, RECQ3, RECQL2, recql2, RECQL3, recql3, RGD1564788, xBLM, xwrnProtein level used designations for RECQL2
- DNA helicase, RecQ-like type 3
- Werner syndrome ATP-dependent helicase
- exonuclease WRN
- recQ protein-like 2
- RECQL2
- Werner syndrome ATP-dependent helicase homolog
- focus forming activity 1
- focus-forming activity 1
- Werner syndrome, RecQ helicase-like
- similar to Werner syndrome helicase homolog
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