RCHY1 Products
(Ring Finger and CHY Zinc Finger Domain Containing 1, E3 Ubiquitin Protein Ligase (RCHY1))
Categories
The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including TP53, HDAC1 and CDKN1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
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Featured RCHY1 Categories
RCHY1 Antibodies
High quality antibodies with extensive validation data.
RCHY1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RCHY1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (4)
Cat. No.
ABIN1724723
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7168232
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN525493
Quantity
100 μg
Datasheet
Datasheet
Recommended RCHY1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6234455
Quantity
96 tests
Datasheet
Datasheet
Recommended RCHY1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317698
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317696
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2131528
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our RCHY1 products
: "p27kip1 Expression in non-small cell lung cancer is not an independent prognostic factor." in: Anticancer research, Vol. 30, Issue 9, pp. 3699-704, (2010) (PubMed).: "The Pirh2-keratin 8/18 interaction modulates the cellular distribution of mitochondria and UV-induced apoptosis." in: Cell death and differentiation, Vol. 16, Issue 6, pp. 826-37, (2009) (PubMed).
: "Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains." in: The Journal of biological chemistry, Vol. 284, Issue 33, pp. 21955-70, (2009) (PubMed).
: "Molecular basis of Pirh2-mediated p53 ubiquitylation." in: Nature structural & molecular biology, Vol. 15, Issue 12, pp. 1334-42, (2008) (PubMed).
: "Phosphorylation of Pirh2 by calmodulin-dependent kinase II impairs its ability to ubiquitinate p53." in: The EMBO journal, Vol. 26, Issue 13, pp. 3062-74, (2007) (PubMed).
: "Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells." in: Experimental cell research, Vol. 312, Issue 17, pp. 3370-8, (2006) (PubMed).
: "Activation of p53 in cervical cancer cells by human papillomavirus E6 RNA interference is transient, but can be sustained by inhibiting endogenous nuclear export-dependent p53 antagonists." in: Cancer research, Vol. 66, Issue 24, pp. 11817-24, (2006) (PubMed).
: "Myeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3." in: The EMBO journal, Vol. 24, Issue 9, pp. 1739-49, (2005) (PubMed).
: "Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer." in: Journal of the National Cancer Institute, Vol. 96, Issue 22, pp. 1718-21, (2004) (PubMed).
Synonyms and alternative names related to RCHY1
ring finger and CHY zinc finger domain containing 1 (RCHY1), ring finger and CHY zinc finger domain containing 1 (Rchy1), ring finger and CHY zinc finger domain containing 1 (rchy1), ring finger and CHY zinc finger domain containing 1 L homeolog (rchy1.L), ARNIP, arnip, CHIMP, chimp, harnip, PIRH2, Pirh2, pirh2, PRO1996, pro1996, RCHY1, RNF199, rnf199, wu:fb37e07, Zfp363, zgc:101128, ZNF363, Znf363, znf363Protein level used designations for RCHY1
- CH-rich interacting match with PLAG1
- E3 ubiquitin-protein ligase Pirh2
- RING finger and CHY zinc finger domain-containing protein 1
- RING finger protein 199
- androgen-receptor N-terminal-interacting protein
- p53-induced protein with a RING-H2 domain
- zinc finger protein 363
- CH-rich-interacting match with PLAG1
- androgen receptor N-terminal-interacting protein
- ring finger and CHY zinc finger domain containing 1
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