RC3H1 Products
(Ring Finger and CCCH-Type Domains 1 (RC3H1))
Categories
RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005 [PubMed 15917799]). The roquin protein is distinguished by the presence of a CCCH zinc finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and stability.[supplied by OMIM, Mar 2008].
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Featured RC3H1 Categories
RC3H1 Antibodies
High quality antibodies with extensive validation data.
RC3H1 ELISA Kits
Reliable ELISA kits for a wide range of species.
RC3H1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RC3H1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN7270049
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF
Validations
Cat. No.
ABIN6991828
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IP
Validations
Cat. No.
ABIN7452216
Quantity
100 μg
Datasheet
Datasheet
Recommended RC3H1 ELISA Kits
Recommended RC3H1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3094903
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3135151
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2730649
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our RC3H1 products
: "Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis." in: Nature communications, Vol. 6, pp. 6253, (2015) (PubMed).: "RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway." in: Nature communications, Vol. 6, pp. 7367, (2015) (PubMed).
: "Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation." in: eLife, Vol. 4, (2015) (PubMed).
: "ROQUIN/RC3H1 alterations are not found in angioimmunoblastic T-cell lymphoma." in: PLoS ONE, Vol. 8, Issue 6, pp. e64536, (2013) (PubMed).
: "The role of Roquin overexpression in the modulation of signaling during in vitro and ex vivo T-cell activation." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 280-6, (2012) (PubMed).
: "Loss of Roquin induces early death and immune deregulation but not autoimmunity." in: The Journal of experimental medicine, Vol. 208, Issue 9, pp. 1749-56, (2011) (PubMed).
: "Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity." in: The Journal of biological chemistry, Vol. 286, Issue 33, pp. 28833-43, (2011) (PubMed).
: "The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs." in: The FEBS journal, Vol. 277, Issue 9, pp. 2109-27, (2010) (PubMed).
Synonyms and alternative names related to RC3H1
ring finger and CCCH-type domains 1 (RC3H1), ring finger and CCCH-type domains 1a (rc3h1a), ring finger and CCCH-type zinc finger domains 1 (RC3H1), RING CCCH (C3H) domains 1 (Rc3h1), ring finger and CCCH-type domains 1 (Rc3h1), ring finger and CCCH-type domains 1 L homeolog (rc3h1.L), 5730557L09Rik, Gm551, mKIAA2025, N28103, RC3H1, rc3h1, RGD1563512, RNF198, ROQUIN, si:dkey-192m14.4Protein level used designations for RC3H1
- RING finger and C3H zinc finger protein 1
- RING finger protein 198
- probable E3 ubiquitin-protein ligase Roquin
- ring finger and CCCH-type zinc finger domains 1
- roquin
- roquin-like
- ring finger and CCCH-type domains 1
- protein Sanroque
- RING CCCH (C3H) domains 1
- RING finger and CCCH-type zinc finger domain-containing protein 1
- roquin-1
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