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RC3H1 Products

(Ring Finger and CCCH-Type Domains 1 (RC3H1))
RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005 [PubMed 15917799]). The roquin protein is distinguished by the presence of a CCCH zinc finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and stability.[supplied by OMIM, Mar 2008].

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Featured RC3H1 Categories

RC3H1 Antibodies

High quality antibodies with extensive validation data.

RC3H1 ELISA Kits

Reliable ELISA kits for a wide range of species.

RC3H1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RC3H1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN7270049
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC (p), IF
Validations
Cat. No. ABIN6991828
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IP
Validations
Cat. No. ABIN7452216
Quantity 100 μg
Datasheet Datasheet

Recommended RC3H1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1156308
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1156309
Quantity 96 tests
Datasheet Datasheet

Recommended RC3H1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3094903
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3135151
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2730649
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our RC3H1 products

Srivastava, Duan, Kershaw, Athanasopoulos, Yeo, Ose, Hu, Brown, Jergic, Patel, Pratama, Richards, Verma, Jones, Heissmeyer, Preiss, Dixon, Chong, Babon, Vinuesa: "Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis." in: Nature communications, Vol. 6, pp. 6253, (2015) (PubMed).

Murakawa, Hinz, Mothes, Schuetz, Uhl, Wyler, Yasuda, Mastrobuoni, Friedel, Dölken, Kempa, Schmidt-Supprian, Blüthgen, Backofen, Heinemann, Wolf, Scheidereit, Landthaler: "RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway." in: Nature communications, Vol. 6, pp. 7367, (2015) (PubMed).

Ramiscal, Parish, Lee-Young, Babon, Blagih, Pratama, Martin, Hawley, Cappello, Nieto, Ellyard, Kershaw, Sweet, Goodnow, Jones, Febbraio, Vinuesa, Athanasopoulos: "Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation." in: eLife, Vol. 4, (2015) (PubMed).

Auguste, Travert, Tarte, Amé-Thomas, Artchounin, Martin-Garcia, de Reynies, de Leval, Gaulard, Delfau-Larue: "ROQUIN/RC3H1 alterations are not found in angioimmunoblastic T-cell lymphoma." in: PLoS ONE, Vol. 8, Issue 6, pp. e64536, (2013) (PubMed).

Kim, Ji, Kim, Yu, Shin, Yuh, Bae, Park, Yi, Kim, Park, Yoon, Lee, Lee, Ryoo: "The role of Roquin overexpression in the modulation of signaling during in vitro and ex vivo T-cell activation." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 280-6, (2012) (PubMed).

Bertossi, Aichinger, Sansonetti, Lech, Neff, Pal, Wunderlich, Anders, Klein, Schmidt-Supprian: "Loss of Roquin induces early death and immune deregulation but not autoimmunity." in: The Journal of experimental medicine, Vol. 208, Issue 9, pp. 1749-56, (2011) (PubMed).

Yan, Cao, Reilly, Young, Garcia, Mishra: "Histone deacetylase 9 deficiency protects against effector T cell-mediated systemic autoimmunity." in: The Journal of biological chemistry, Vol. 286, Issue 33, pp. 28833-43, (2011) (PubMed).

Athanasopoulos, Barker, Yu, Tan, Srivastava, Contreras, Wang, Lam, Brown, Goodnow, Dixon, Leedman, Saint, Vinuesa: "The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs." in: The FEBS journal, Vol. 277, Issue 9, pp. 2109-27, (2010) (PubMed).

Synonyms and alternative names related to RC3H1

ring finger and CCCH-type domains 1 (RC3H1), ring finger and CCCH-type domains 1a (rc3h1a), ring finger and CCCH-type zinc finger domains 1 (RC3H1), RING CCCH (C3H) domains 1 (Rc3h1), ring finger and CCCH-type domains 1 (Rc3h1), ring finger and CCCH-type domains 1 L homeolog (rc3h1.L), 5730557L09Rik, Gm551, mKIAA2025, N28103, RC3H1, rc3h1, RGD1563512, RNF198, ROQUIN, si:dkey-192m14.4

Protein level used designations for RC3H1

  • RING finger and C3H zinc finger protein 1
  • RING finger protein 198
  • probable E3 ubiquitin-protein ligase Roquin
  • ring finger and CCCH-type zinc finger domains 1
  • roquin
  • roquin-like
  • ring finger and CCCH-type domains 1
  • protein Sanroque
  • RING CCCH (C3H) domains 1
  • RING finger and CCCH-type zinc finger domain-containing protein 1
  • roquin-1
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