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RASGRP4 Products

(RAS Guanyl Releasing Protein 4 (RASGRP4))

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The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009].

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Featured RASGRP4 Categories

RASGRP4 Antibodies

High quality antibodies with extensive validation data.

RASGRP4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RASGRP4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (1)
  • (3)
Cat. No. ABIN566740
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p), IF, ICC
Validations
  • (3)
Cat. No. ABIN2855910
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, PLA
Validations
  • (2)
Cat. No. ABIN530350
Quantity 100 μg
Datasheet Datasheet

Recommended RASGRP4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1317507
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1317506
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3081014
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our RASGRP4 products

Shalom-Feuerstein, Levy, Makovski, Raz, Kloog: "Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras." in: Biochimica et biophysica acta, Vol. 1783, Issue 6, pp. 985-93, (2008) (PubMed).

Reuther, Lambert, Rebhun, Caligiuri, Quilliam, Der: "RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia." in: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 30508-14, (2002) (PubMed).

Synonyms and alternative names related to RASGRP4

RAS guanyl releasing protein 4 (RASGRP4), RAS guanyl releasing protein 4 (rasgrp4), RAS guanyl releasing protein 4 (Rasgrp4), RASGRP4

Protein level used designations for RASGRP4

  • RAS guanyl releasing protein 4
  • RAS guanyl-releasing protein 4-like
  • RAS guanyl-releasing protein 4
  • guanyl nucleotide releasing protein 4
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