RASGRP4 Products
(RAS Guanyl Releasing Protein 4 (RASGRP4))
Categories
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009].
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Featured RASGRP4 Categories
RASGRP4 Antibodies
High quality antibodies with extensive validation data.
RASGRP4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RASGRP4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN566740
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p), IF, ICC
Validations
- (3)
Cat. No.
ABIN2855910
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, PLA
Validations
- (2)
Cat. No.
ABIN530350
Quantity
100 μg
Datasheet
Datasheet
Recommended RASGRP4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317507
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317506
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3081014
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RASGRP4 products
: "Galectin-3 regulates RasGRP4-mediated activation of N-Ras and H-Ras." in: Biochimica et biophysica acta, Vol. 1783, Issue 6, pp. 985-93, (2008) (PubMed).: "RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia." in: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 30508-14, (2002) (PubMed).
Synonyms and alternative names related to RASGRP4
RAS guanyl releasing protein 4 (RASGRP4), RAS guanyl releasing protein 4 (rasgrp4), RAS guanyl releasing protein 4 (Rasgrp4), RASGRP4Protein level used designations for RASGRP4
- RAS guanyl releasing protein 4
- RAS guanyl-releasing protein 4-like
- RAS guanyl-releasing protein 4
- guanyl nucleotide releasing protein 4
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