RASA1 Products
(RAS P21 Protein Activator (GTPase Activating Protein) 1 (RASA1))
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The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012].
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Featured RASA1 Categories
RASA1 Antibodies
High quality antibodies with extensive validation data.
RASA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
RASA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RASA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (4)
Cat. No.
ABIN562592
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN519660
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p), IHC (fro), ICC
Validations
- (2)
Cat. No.
ABIN7443047
Quantity
100 μL
Datasheet
Datasheet
Recommended RASA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
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Datasheet
Reactivity
Goat
Analytical Method
Competition ELISA
Validations
Cat. No.
ABIN995296
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Competition ELISA
Validations
Cat. No.
ABIN1057985
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1154493
Quantity
96 tests
Datasheet
Datasheet
Recommended RASA1 Proteins
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317466
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317464
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7416016
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our RASA1 products
: "Eph-B4 prevents venous adaptive remodeling in the adult arterial environment." in: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 561-75, (2011) (PubMed).: "Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor." in: Genes & development, Vol. 17, Issue 4, pp. 449-54, (2003) (PubMed).
: "Annexin V inhibits the 12-O-tetradecanoylphorbol-13-acetate-induced activation of Ras/extracellular signal-regulated kinase (ERK) signaling pathway upstream of Shc in MCF-7 cells." in: Oncogene, Vol. 19, Issue 25, pp. 2904-12, (2000) (PubMed).
: "Formation of complexes involving RasGAP and p190 RhoGAP during morphogenetic events of the gastrulation in xenopus." in: European journal of biochemistry / FEBS, Vol. 265, Issue 2, pp. 530-8, (1999) (PubMed).
: "PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex." in: Cell, Vol. 61, Issue 1, pp. 125-33, (1990) (PubMed).
: "PDGF induction of tyrosine phosphorylation of GTPase activating protein." in: Nature, Vol. 342, Issue 6250, pp. 711-4, (1990) (PubMed).
Synonyms and alternative names related to RASA1
vacuolar peduncle (vap), RAS p21 protein activator 1 (RASA1), RAS p21 protein activator 1 (Rasa1), CG9209, CM-AVM, CMAVM, D-RasGAP, Dmel\\CG9209, GAP, Gap, GAPX, p120GAP, p120RASGAP, PKWS, RAS-GAP, RASA, Rasa, RasGAP, RasGap, rasGap, RASGAPProtein level used designations for RASA1
- CG9209-PA
- CG9209-PB
- CG9209-PC
- CG9209-PD
- Ras GTPase-activating protein
- vacuolar peduncule
- vacuolar pedunculi
- vap-PA
- vap-PB
- vap-PC
- vap-PD
- ras GTPase-activating protein 1
- triphosphatase-activating protein
- GAP
- GTPase-activating protein
- RAS p21 protein activator (GTPase activating protein RAS p21)
- p120GAP
- rasGAP
- RAS p21 protein activator 1
- p120-rasGAP
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