RAPGEF2 Products
(Rap Guanine Nucleotide Exchange Factor (GEF) 2 (RAPGEF2))
Categories
Members of the RAS (see HRAS\; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008].
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Featured RAPGEF2 Categories
RAPGEF2 Antibodies
High quality antibodies with extensive validation data.
RAPGEF2 ELISA Kits
Reliable ELISA kits for a wide range of species.
RAPGEF2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RAPGEF2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
- (2)
Cat. No.
ABIN564181
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat, Xenopus laevis, Zebrafish (Danio rerio)
Application
WB
Validations
- (1)
- (1)
Cat. No.
ABIN6746202
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
- (3)
Cat. No.
ABIN2775568
Quantity
100 μL
Datasheet
Datasheet
Recommended RAPGEF2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative
Validations
Cat. No.
ABIN510241
Quantity
96 tests
Datasheet
Datasheet
Recommended RAPGEF2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317410
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095077
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136471
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RAPGEF2 products
: "Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP." in: The Journal of biological chemistry, Vol. 291, Issue 41, pp. 21584-21595, (2016) (PubMed).: "Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells." in: Science signaling, Vol. 6, Issue 281, pp. ra51, (2013) (PubMed).
: "NEDD4-1 regulates migration and invasion of glioma cells through CNrasGEF ubiquitination in vitro." in: PLoS ONE, Vol. 8, Issue 12, pp. e82789, (2013) (PubMed).
: "Rap2A links intestinal cell polarity to brush border formation." in: Nature cell biology, Vol. 14, Issue 8, pp. 793-801, (2012) (PubMed).
: "Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control." in: Cellular signalling, Vol. 23, Issue 12, pp. 2056-64, (2011) (PubMed).
: "PKC-theta selectively controls the adhesion-stimulating molecule Rap1." in: Blood, Vol. 112, Issue 12, pp. 4617-27, (2008) (PubMed).
: "Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein." in: The Journal of biological chemistry, Vol. 271, Issue 13, pp. 7802-10, (1996) (PubMed).
Synonyms and alternative names related to RAPGEF2
Rap guanine nucleotide exchange factor 2 (RAPGEF2), Rap guanine nucleotide exchange factor 2 L homeolog (rapgef2.L), Rap guanine nucleotide exchange factor (GEF) 2 (RAPGEF2), Rap guanine nucleotide exchange factor (GEF) 2 (rapgef2), Rap guanine nucleotide exchange factor 2 (rapgef2), Rap guanine nucleotide exchange factor (GEF) 2 (Rapgef2), Rap guanine nucleotide exchange factor 2 (Rapgef2), 5830453M24Rik, CNrasGEF, CNRasGEF, fa11h07, MGC83978, mKIAA0313, NRAPGEP, nRap GEP, nRapGEP, PDZ-GEF1, PDZGEF1, Pdzgef1, RA-GEF, RA-GEF-1, Rap-GEP, RAPGEF2, wu:fa11h07Protein level used designations for RAPGEF2
- Rap guanine nucleotide exchange factor (GEF) 2
- rap guanine nucleotide exchange factor 2
- Rap guanine nucleotide exchange factor 2-like
- rap guanine nucleotide exchange factor 2-like
- PDZ domain containing guanine nucleotide exchange factor (GEF) 1
- PDZ domain-containing guanine nucleotide exchange factor 1
- RA(Ras/Rap1A-associating)-GEF
- neural RAP guanine nucleotide exchange protein
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