RAF1 Products
(V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1 (RAF1))
Categories
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008].
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Featured RAF1 Categories
RAF1 Antibodies
High quality antibodies with extensive validation data.
RAF1 ELISA Kits
Reliable ELISA kits for a wide range of species.
RAF1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RAF1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (2)
- (1)
Cat. No.
ABIN733208
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (1)
- (7)
Cat. No.
ABIN3020713
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, FACS
Validations
- (2)
- (5)
Cat. No.
ABIN969560
Quantity
100 μL
Datasheet
Datasheet
Recommended RAF1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960422
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380689
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380400
Quantity
2 x 96 tests
Datasheet
Datasheet
Recommended RAF1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1317314
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317315
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5509125
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our RAF1 products
: "Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer." in: Cancer medicine, Vol. 7, Issue 4, pp. 1546-1559, (2018) (PubMed).: "EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer." in: Molecular medicine reports, Vol. 17, Issue 6, pp. 7875-7885, (2018) (PubMed).
: "Wogonoside induces depalmitoylation and translocation of PLSCR1 and N-RAS in primary acute myeloid leukaemia cells." in: Journal of cellular and molecular medicine, Vol. 22, Issue 4, pp. 2117-2130, (2018) (PubMed).
: "Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf-ERK pathway." in: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 277-284, (2017) (PubMed).
: "Type II cGMP-dependent protein kinase negatively regulates fibroblast growth factor signaling by phosphorylating Raf-1 at serine 43 in rat chondrosarcoma cells." in: Biochemical and biophysical research communications, Vol. 483, Issue 1, pp. 82-87, (2017) (PubMed).
: "Zika virus cell tropism in the developing human brain and inhibition by azithromycin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 50, pp. 14408-14413, (2016) (PubMed).
: "The role of Dectin-1/Raf-1 signal cascade in innate immune of human corneal epithelial cells against Aspergillus fumigatus infection." in: International journal of ophthalmology, Vol. 9, Issue 10, pp. 1371-1375, (2016) (PubMed).
: "Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling." in: eLife, Vol. 5, (2016) (PubMed).
: "The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux." in: Autophagy, Vol. 11, Issue 8, pp. 1373-88, (2015) (PubMed).
: "Bone marrow mononuclear cell transplantation promotes therapeutic angiogenesis via upregulation of the VEGF-VEGFR2 signaling pathway in a rat model of vascular dementia." in: Behavioural brain research, Vol. 265, pp. 171-80, (2014) (PubMed).
Synonyms and alternative names related to RAF1
Raf-1 proto-oncogene, serine/threonine kinase (RAF1), Raf-1 proto-oncogene, serine/threonine kinase (Raf1), Raf-1 proto-oncogene, serine/threonine kinase a (raf1a), Raf-1 proto-oncogene, serine/threonine kinase (raf1), v-raf-leukemia viral oncogene 1 (Raf1), Raf-1 proto-oncogene, serine/threonine kinase S homeolog (raf1.S), 6430402F14Rik, AA990557, BB129353, c-Raf, c-raf, CRAF, craf, cRaf, Craf1, D830050J10Rik, NS5, raf, Raf-1, raf1, RAF1, v-RafProtein level used designations for RAF1
- Oncogene RAF1
- RAF proto-oncogene serine/threonine-protein kinase
- proto-oncogene c-RAF
- raf proto-oncogene serine/threonine protein kinase
- C-RAF
- cRaf
- murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
- raf-1
- v-raf-1 murine leukemia viral oncogene homolog 1
- murine leukemia viral oncogene homolog
- serine/threonine protein kinase RAF1
- MIL proto-oncogene serine/threonine-protein kinase
- RAF-1
- c-mil protein
- murine leukemia viral (v-raf-1) oncogene homolog 1
- RAF proto-oncogene serine/threonine-protein kinase-like
- Craf1 transforming
- murine sarcoma 3611 oncogene 1
- sarcoma 3611 oncogene
- v-raf-1 leukemia viral oncogene 1
- Proto-oncogene c-RAF
- Raf-1
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