RAD18 Products
(E3 ubiquitin-protein ligase RAD18 (RAD18))
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The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008].
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Featured RAD18 Categories
RAD18 Antibodies
High quality antibodies with extensive validation data.
RAD18 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RAD18 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), RNAi
Validations
- (7)
- (8)
Cat. No.
ABIN566046
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN5542377
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (4)
Cat. No.
ABIN950100
Quantity
100 μL
Datasheet
Datasheet
Recommended RAD18 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317270
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317268
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2730398
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our RAD18 products
: "Ablation of Ggnbp2 impairs meiotic DNA double-strand break repair during spermatogenesis in mice." in: Journal of cellular and molecular medicine, Vol. 22, Issue 10, pp. 4863-4874, (2018) (PubMed).: "DNA Polymerase Eta Prevents Tumor Cell-Cycle Arrest and Cell Death during Recovery from Replication Stress." in: Cancer research, Vol. 78, Issue 23, pp. 6549-6560, (2018) (PubMed).
: "HUWE1 interacts with PCNA to alleviate replication stress." in: EMBO reports, Vol. 17, Issue 6, pp. 874-86, (2016) (PubMed).
: "USP7 is essential for maintaining Rad18 stability and DNA damage tolerance." in: Oncogene, Vol. 35, Issue 8, pp. 965-76, (2016) (PubMed).
: "Evidence for ubiquitin-regulated nuclear and subnuclear trafficking among Paramyxovirinae matrix proteins." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004739, (2015) (PubMed).
: "The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks." in: Nucleic acids research, Vol. 41, Issue 18, pp. 8572-80, (2013) (PubMed).
: "Elevated expression of Rad18 regulates melanoma cell proliferation." in: Pigment cell & melanoma research, Vol. 25, Issue 2, pp. 213-8, (2012) (PubMed).
: "Phosphorylation of human INO80 is involved in DNA damage tolerance." in: Biochemical and biophysical research communications, Vol. 417, Issue 1, pp. 433-8, (2012) (PubMed).
: "Tumour suppressor ING1b maintains genomic stability upon replication stress." in: Nucleic acids research, Vol. 39, Issue 9, pp. 3632-42, (2011) (PubMed).
: "NBS1 recruits RAD18 via a RAD6-like domain and regulates Pol ?-dependent translesion DNA synthesis." in: Molecular cell, Vol. 43, Issue 5, pp. 788-97, (2011) (PubMed).
Synonyms and alternative names related to RAD18
RAD18, E3 ubiquitin protein ligase (RAD18), RAD18 E3 ubiquitin protein ligase (Rad18), RAD18 E3 ubiquitin protein ligase (rad18), E3 ubiquitin-protein ligase RAD18 (RAD18), E3 ubiquitin-protein ligase (RAD18), DNA repair protein and ATPase (RAD18), C3HC4-type zinc finger-containing protein (rad18), RAD18, E3 ubiquitin protein ligase (Rad18), 2810024C04Rik, DDBDRAFT_0218120, DDBDRAFT_0304878, DDB_0218120, DDB_0304878, DKFZp469H0810, RAD18, Rad18sc, RNF73, zgc:55577Protein level used designations for RAD18
- E3 ubiquitin-protein ligase RAD18
- RAD18, S. cerevisiae, homolog
- RING finger protein 73
- hHR18
- hRAD18
- postreplication repair protein RAD18
- postreplication repair protein hRAD18p
- mRAD18Sc
- post-replication repair protein RAD18SC
- RAD18 homolog (S. cerevisiae)
- similar to postreplication repair protein hRAD18p
- E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair
- Rad18p
- hypothetical protein
- DNA repair protein and ATPase
- SAP DNA-binding domain-containing protein
- RAD18 homolog
- RAD18-like protein
- E3 ubiquitin-protein ligase RAD18-like
- e3 ubiquitin-protein ligase RAD18-like
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