RAB8A Products
(RAB8A, Member RAS Oncogene Family (RAB8A))
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The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008].
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Featured RAB8A Categories
RAB8A Antibodies
High quality antibodies with extensive validation data.
RAB8A ELISA Kits
Reliable ELISA kits for a wide range of species.
RAB8A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RAB8A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (2)
- (4)
Cat. No.
ABIN1881723
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN5542342
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (4)
Cat. No.
ABIN561805
Quantity
100 μg
Datasheet
Datasheet
Recommended RAB8A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969818
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1154795
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1154790
Quantity
96 tests
Datasheet
Datasheet
Recommended RAB8A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317201
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317203
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2730373
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our RAB8A products
: "Transcription factor EB‑mediated autophagy promotes dermal fibroblast differentiation and collagen production by regulating endoplasmic reticulum stress and autophagy‑dependent secretion." in: International journal of molecular medicine, Vol. 47, Issue 2, pp. 547-560, (2021) (PubMed).: "Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3." in: The Journal of cell biology, Vol. 211, Issue 3, pp. 587-604, (2015) (PubMed).
: "Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function." in: Human molecular genetics, Vol. 23, Issue 11, pp. 2834-46, (2014) (PubMed).
: "Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women." in: Human reproduction (Oxford, England), Vol. 25, Issue 11, pp. 2870-7, (2010) (PubMed).
: "Functional dissection of Rab GTPases involved in primary cilium formation." in: The Journal of cell biology, Vol. 178, Issue 3, pp. 363-9, (2007) (PubMed).
: "Rab27a: A key to melanosome transport in human melanocytes." in: The Journal of cell biology, Vol. 152, Issue 4, pp. 843-50, (2001) (PubMed).
: "Rab27a regulates the peripheral distribution of melanosomes in melanocytes." in: The Journal of cell biology, Vol. 152, Issue 4, pp. 795-808, (2001) (PubMed).
: "Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation." in: Molecular biology of the cell, Vol. 11, Issue 1, pp. 393-412, (2000) (PubMed).
: "Construction of a human full-length cDNA bank." in: Gene, Vol. 150, Issue 2, pp. 243-50, (1995) (PubMed).
: "A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells." in: The Journal of cell biology, Vol. 124, Issue 1-2, pp. 101-15, (1994) (PubMed).
Synonyms and alternative names related to RAB8A
rab8A protein (rab8A), Rab GTPase (rab8A), RAB8A, member RAS oncogene family (RAB8A), RAB8A, member RAS oncogene family (rab8a), RAB8A, member RAS oncogene family S homeolog (rab8a.S), RAB8A, member RAS oncogene family (Rab8a), AA409338, c-mel, DDBDRAFT_0206521, DDBDRAFT_0214885, DDB_0206521, DDB_0214885, HSH2D, mel, MEL, Mel, rab8, RAB8, Rab8, rab8A, zgc:162699Protein level used designations for RAB8A
- rab8A protein
- hematopoietic SH2 domain containing
- ras-related protein Rab-8A
- RAB8A, member RAS oncogene family
- member RAS oncogene family
- Ras-related protein Rab-8A
- mel transforming oncogene (RAB8 homolog)
- mel transforming oncogene (derived from cell line NK14)
- mel transforming oncogene (derived from cell line NK14)- RAB8 homolog
- oncogene c-mel
- ras-associated protein RAB8
- RAB8, member RAS oncogene family
- cell line NK14 derived transforming oncogene
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