RAB7B Products
(RAB7B, Member RAS Oncogene Family (RAB7B))
Categories
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway (By similarity).
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Featured RAB7B Categories
RAB7B Antibodies
High quality antibodies with extensive validation data.
RAB7B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended RAB7B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IP
Validations
- (6)
- (6)
Cat. No.
ABIN567027
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
- (1)
Cat. No.
ABIN1881722
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN531619
Quantity
100 μg
Datasheet
Datasheet
Recommended RAB7B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317195
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317197
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3086874
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RAB7B products
: "Rab7a regulates cell migration through Rac1 and vimentin." in: Biochimica et biophysica acta, Vol. 1864, Issue 2, pp. 367-381, (2016) (PubMed).: "A novel interaction between Rab7b and actomyosin reveals a dual role in intracellular transport and cell migration." in: Journal of cell science, Vol. 127, Issue 22, pp. 4927-39, (2014) (PubMed).
: "Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells." in: Molecular biology of the cell, Vol. 22, Issue 10, pp. 1699-715, (2011) (PubMed).
: "GIGYF2 is present in endosomal compartments in the mammalian brains and enhances IGF-1-induced ERK1/2 activation." in: Journal of neurochemistry, Vol. 115, Issue 2, pp. 423-37, (2010) (PubMed).
: "Rab7b controls trafficking from endosomes to the TGN." in: Journal of cell science, Vol. 123, Issue Pt 9, pp. 1480-91, (2010) (PubMed).
: "SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery." in: Molecular biology of the cell, Vol. 20, Issue 4, pp. 1223-40, (2009) (PubMed).
: "Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease." in: Journal of neuropathology and experimental neurology, Vol. 68, Issue 9, pp. 994-1005, (2009) (PubMed).
: "Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells." in: Biochemical and biophysical research communications, Vol. 318, Issue 3, pp. 792-9, (2004) (PubMed).
Synonyms and alternative names related to RAB7B
Rab7b, member RAS oncogene family (Rab7b), rab7B protein (rab7B), RAB7B, member RAS oncogene family (RAB7B), RAB7B, member RAS oncogene family S homeolog (rab7b.S), RAB7B, member RAS oncogene family (rab7b), RAB7B, member RAS oncogene family (Rab7b), RAB7, RAB7B, Rab7b, RGD1562617Protein level used designations for RAB7B
- ras-related protein Rab-7b
- rab7B protein
- RAB7B, member RAS oncogene family
- Ras-related protein Rab-7
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