PYGL Products
(phosphorylase, Glycogen, Liver (PYGL))
Categories
This gene encodes a homodimeric protein that catalyses the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. This protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity of this enzyme is further regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes that encode distinct isozymes that are primarily expressed in liver, brain and muscle, respectively. The liver isozyme serves the glycemic demands of the body in general while the brain and muscle isozymes supply just those tissues. In glycogen storage disease type VI, also known as Hers disease, mutations in liver glycogen phosphorylase inhibit the conversion of glycogen to glucose and results in moderate hypoglycemia, mild ketosis, growth retardation and hepatomegaly. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2011].
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Featured PYGL Categories
PYGL Antibodies
High quality antibodies with extensive validation data.
PYGL ELISA Kits
Reliable ELISA kits for a wide range of species.
PYGL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PYGL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7438019
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, IF
Validations
- (5)
Cat. No.
ABIN6146525
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (4)
Cat. No.
ABIN7154210
Quantity
100 μg
Datasheet
Datasheet
Recommended PYGL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (5)
Cat. No.
ABIN6574226
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969315
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
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Validations
- (1)
Cat. No.
ABIN6958582
Quantity
96 tests
Datasheet
Datasheet
Recommended PYGL Proteins
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124446
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316980
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN5623740
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PYGL products
: "Expression of glycogen phosphorylase isoforms in cultured muscle from patients with McArdle's disease carrying the p.R771PfsX33 PYGM mutation." in: PLoS ONE, Vol. 5, Issue 10, (2010) (PubMed).Synonyms and alternative names related to PYGL
glycogen phosphorylase L (PYGL), phosphorylase, glycogen, liver (pygl), phosphorylase, glycogen, liver S homeolog (pygl.S), liver glycogen phosphorylase (Pygl), glycogen phosphorylase L (Pygl), GSD6, zgc:66314Protein level used designations for PYGL
- glycogen phosphorylase, liver form
- liver glycogen phosphorylase
- phosphorylase, glycogen; liver (Hers disease, glycogen storage disease type VI)
- glycogen storage disease type VI-related protein
- phosphorylase, glycogen; liver
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