PYCARD Products
(PYD and CARD Domain Containing (PYCARD))
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This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured PYCARD Categories
PYCARD Antibodies
High quality antibodies with extensive validation data.
PYCARD ELISA Kits
Reliable ELISA kits for a wide range of species.
PYCARD Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PYCARD Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (1)
- (7)
Cat. No.
ABIN6146515
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (7)
Cat. No.
ABIN3021617
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (6)
Cat. No.
ABIN184674
Quantity
100 μg
Datasheet
Datasheet
Recommended PYCARD ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969788
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969787
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6976147
Quantity
96 tests
Datasheet
Datasheet
Recommended PYCARD Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1316968
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3089316
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137154
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our PYCARD products
: "PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse." in: Ecotoxicology and environmental safety, Vol. 169, pp. 551-563, (2019) (PubMed).: "AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model." in: Life sciences, Vol. 221, pp. 249-258, (2019) (PubMed).
: "Evaluation of Canonical Inflammasome Activation in Human Monocytes by Imaging Flow Cytometry." in: Frontiers in immunology, Vol. 10, pp. 1284, (2019) (PubMed).
: "NLRP3 inflammasome activation in platelets in response to sepsis." in: Physiological reports, Vol. 7, Issue 9, pp. e14073, (2019) (PubMed).
: "Ozone protects the rat lung from ischemia-reperfusion injury by attenuating NLRP3-mediated inflammation, enhancing Nrf2 antioxidant activity and inhibiting apoptosis." in: European journal of pharmacology, Vol. 835, pp. 82-93, (2018) (PubMed).
: "Oral Administration of Compound Probiotics Ameliorates HFD-Induced Gut Microbe Dysbiosis and Chronic Metabolic Inflammation via the G Protein-Coupled Receptor 43 in Non-alcoholic Fatty Liver Disease ..." in: Probiotics and antimicrobial proteins, (2018) (PubMed).
: "S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking." in: Cell reports, Vol. 22, Issue 9, pp. 2431-2441, (2018) (PubMed).
: "NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media." in: Acta oto-laryngologica, Vol. 138, Issue 12, pp. 1061-1065, (2018) (PubMed).
: "Actin polymerization plays a significant role in asbestos-induced inflammasome activation in mesothelial cells in vitro." in: Histochemistry and cell biology, Vol. 147, Issue 5, pp. 595-604, (2018) (PubMed).
: "Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis." in: Journal of virology, Vol. 91, Issue 24, (2017) (PubMed).
Synonyms and alternative names related to PYCARD
PYD and CARD domain containing (PYCARD), PYD and CARD domain containing (Pycard), PYD and CARD domain containing (pycard), 9130417A21Rik, ASC, Asc, asc1, CARD5, masc, TMS, TMS-1, TMS1, TNS1, zAsc, zgc:109874Protein level used designations for PYCARD
- apoptosis-associated speck-like protein containing a CARD
- caspase recruitment domain-containing protein 5
- target of methylation-induced silencing 1
- PYD and CARD domain-containing protein
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