PUMA Products
(BCL2 Binding Component 3 (BBC3))
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This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011].
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Featured PUMA Categories
PUMA Antibodies
High quality antibodies with extensive validation data.
PUMA ELISA Kits
Reliable ELISA kits for a wide range of species.
PUMA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PUMA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ICC, IF
Validations
- (6)
Cat. No.
ABIN361748
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Pig, Rat
Application
WB, ELISA, IP, FACS, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (3)
- (4)
Cat. No.
ABIN731528
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p), IF
Validations
- (1)
- (4)
Cat. No.
ABIN388112
Quantity
400 μL
Datasheet
Datasheet
Recommended PUMA ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969127
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969126
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6954053
Quantity
96 tests
Datasheet
Datasheet
Recommended PUMA Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121980
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2730162
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7504951
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PUMA products
: "Wild-Type p53 Promotes Cancer Metabolic Switch by Inducing PUMA-Dependent Suppression of Oxidative Phosphorylation." in: Cancer cell, Vol. 35, Issue 2, pp. 191-203.e8, (2019) (PubMed).: "Temporal and differential regulation of KAISO-controlled transcription by phosphorylated and acetylated p53 highlights a crucial regulatory role of apoptosis." in: The Journal of biological chemistry, Vol. 294, Issue 35, pp. 12957-12974, (2019) (PubMed).
: "Inhibition of REST Suppresses Proliferation and Migration in Glioblastoma Cells." in: International journal of molecular sciences, Vol. 17, Issue 5, (2017) (PubMed).
: "Paradoxical Roles of Elongation Factor-2 Kinase in Stem Cell Survival." in: The Journal of biological chemistry, Vol. 291, Issue 37, pp. 19545-57, (2016) (PubMed).
: "Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway." in: Acta pharmacologica Sinica, Vol. 36, Issue 12, pp. 1514-9, (2016) (PubMed).
: "Detection of Bim and Puma in mouse hair follicles using immunofluorescence and TUNEL assay double staining." in: Biotechnic & histochemistry : official publication of the Biological Stain Commission, pp. 1-7, (2015) (PubMed).
: "p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death." in: Oncogene, (2015) (PubMed).
: "Nerve growth factor reduces apoptotic cell death in rat facial motor neurons after facial nerve injury." in: Neurosciences (Riyadh, Saudi Arabia), Vol. 20, Issue 1, pp. 65-8, (2015) (PubMed).
: "B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins." in: The Journal of biological chemistry, Vol. 289, Issue 38, pp. 26481-91, (2014) (PubMed).
: "A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53." in: Cancer letters, Vol. 356, Issue 2 Pt B, pp. 910-7, (2014) (PubMed).
Synonyms and alternative names related to PUMA
BCL2 binding component 3 (BBC3), Bcl-2 binding component 3 (Bbc3), BCL2 binding component 3 (Bbc3), BCL2 binding component 3 (bbc3), BBC3, JFY-1, JFY1, Puma, PUMA, PUMA/JFY1Protein level used designations for PUMA
- BCL2 binding component 3
- bcl-2-binding component 3
- p53 up-regulated modulator of apoptosis
- BH3-only
- Bcl-2 binding component 3
- Puma
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