PUM1 Products
(Pumilio Homolog 1 (PUM1))
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This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
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Featured PUM1 Categories
PUM1 Antibodies
High quality antibodies with extensive validation data.
PUM1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PUM1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN391822
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN392129
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN6146494
Quantity
100 μL
Datasheet
Datasheet
Recommended PUM1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2730163
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our PUM1 products
: "ABCA1 protein enhances Toll-like receptor 4 (TLR4)-stimulated interleukin-10 (IL-10) secretion through protein kinase A (PKA) activation." in: The Journal of biological chemistry, Vol. 287, Issue 48, pp. 40502-12, (2012) (PubMed).: "NF-Y recruits both transcription activator and repressor to modulate tissue- and developmental stage-specific expression of human γ-globin gene." in: PLoS ONE, Vol. 7, Issue 10, pp. e47175, (2012) (PubMed).
: "Mammalian Pumilio 2 regulates dendrite morphogenesis and synaptic function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 7, pp. 3222-7, (2010) (PubMed).
: "Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets." in: Molecular and cellular biology, Vol. 28, Issue 12, pp. 4093-103, (2008) (PubMed).
: "Polymorphisms of the human PUMILIO2 gene and male sterility." in: Molecular reproduction and development, Vol. 74, Issue 6, pp. 795-9, (2007) (PubMed).
: "Candidate mRNAs interacting with fertility protein PUMILIO2 in the human germ line." in: Reproductive biology, Vol. 6 Suppl 1, pp. 37-42, (2006) (PubMed).
: "High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 42, pp. 15588-93, (2006) (PubMed).
: "Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 538-43, (2003) (PubMed).
Synonyms and alternative names related to PUM1
pumilio RNA-binding family member 1 (pum1), pumilio RNA binding family member 1 (PUM1), pumilio RNA binding family member 1 (pum1), pumilio RNA-binding family member 1 (Pum1), AA517475, DKFZp459K0627, fb96a03, HSPUM, mKIAA0099, PUM1, PUMH, PUMH1, pumilio1, PUML1, Pumm, si:ch211-285e16.1, wu:fb96a03, wu:fb96a08, zgc:63671Protein level used designations for PUM1
- pumilio homolog 1
- pumilio homolog 1 (Drosophila)
- pumilio-1
- pumilio 1
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