PTTG1 Products
(Pituitary Tumor-Transforming 1 (PTTG1))
Categories
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. [provided by RefSeq, Jul 2008].
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Featured PTTG1 Categories
PTTG1 Antibodies
High quality antibodies with extensive validation data.
PTTG1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PTTG1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PTTG1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7444319
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF, FACS
Validations
- (5)
Cat. No.
ABIN6391382
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (1)
- (3)
Cat. No.
ABIN391532
Quantity
400 μL
Datasheet
Datasheet
Recommended PTTG1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6975309
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648205
Quantity
96 tests
Datasheet
Datasheet
Recommended PTTG1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124456
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316899
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1316901
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our PTTG1 products
: "Extraciliary roles of the ciliopathy protein JBTS17 in mitosis and neurogenesis." in: Annals of neurology, Vol. 86, Issue 1, pp. 99-115, (2019) (PubMed).: "Pituitary tumor transforming gene: a novel therapeutic target for glioma treatment." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 6, pp. 414-21, (2015) (PubMed).
: "Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13." in: Tumour biology, (2015) (PubMed).
: "Pituitary tumor-transforming gene 1 (PTTG1) is overexpressed in oral squamous cell carcinoma (OSCC) and promotes migration, invasion and epithelial-mesenchymal transition (EMT) in SCC15 cells." in: Tumour biology, Vol. 35, Issue 9, pp. 8801-11, (2014) (PubMed).
: "PTTG1 oncogene promotes tumor malignancy via epithelial to mesenchymal transition and expansion of cancer stem cell population." in: The Journal of biological chemistry, Vol. 287, Issue 23, pp. 19516-27, (2012) (PubMed).
Synonyms and alternative names related to PTTG1
pituitary tumor-transforming 1 (PTTG1), pituitary tumor-transforming gene 1 (Pttg1), pituitary tumor-transforming 1 (Pttg1), securin, sister chromatid separation inhibitor (cut2), AW555095, C87862, EAP1, HPTTG, Protein Cut2, PTTG, Pttg, PTTG1, Pttg3, securin, Securin, TUTR1Protein level used designations for PTTG1
- ESP1-associated protein 1
- pituitary tumor-transforming gene 1 protein
- securin
- tumor-transforming protein 1
- pituitary tumor-transforming protein 1
- pituitary tumor-transforming 1
- Pituitary tumor transforming
- Pituitary tumor-transforming gene 1 protein
- Cell untimely torn protein 2
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